TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.15.8
Manganese (Mn2+), zinc (Zn2+) and possibly iron (Fe2+) uptake porter, TroABCD (Hazlett et al., 2003).  Transcription of the operon is controlled by the Mn2+-activated (not Zn2+- or Fe2+-activated) repressor, TroR (153 aas, acc# F7IW50;) TroR contains a metal-binding domain homologous to the YtgC-R protein (3.A.1.15.12) which has the membrane domain of this ABC transporter (N-terminus) fused to the repressor domain (C-terminus) (Liu et al. 2013).  TroA (Tromp1), the periplasmic metal binding protein, was originally reported to be an outer membrane porin (Zhang et al. 1999), but this proved to be incorrect.

Accession Number:P96117
Protein Name:TroB
Length:266
Molecular Weight:29360.00
Species:Treponema pallidum [160]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Periplasm1
Substrate Zn2+, Mn2+, Fe2+

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_218603.1   
Entrez Gene ID: 2611123   
Pfam: PF00005   
BioCyc: TPAL243276:TP_0164-MONOMER   
KEGG: tpa:TP0164   

Gene Ontology

GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0006829 P:zinc ion transport

References (2)

[1] “Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.”  Hardham J.M.et.al.   9332349
[2] “Complete genome sequence of Treponema pallidum, the syphilis spirochete.”  Fraser C.M.et.al.   9665876

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAEISATAYA VQVDDLTLAY RQKPVLWDVD VRIPEGVIEA IIGPNGAGKS TLLKAIMGLL 
61:	PLASGEVRVF GRPFSKERRR VAYVPQRSAV DWDFPTTVFD VVLMGSYGSL GWILRPGKRE 
121:	KARAREAIEE VGMGAFLDRQ ISELSGGQQQ RVFLARALVQ DADLYFMDEP FQGVDAATEQ 
181:	AIVTLLKTLK GRGKTLLVVH HDLQTVAEYF DRVLLLNVRV IAEGAVVSAF TEEYVQRAYG 
241:	GRISSTLFPR GNKEDVHDAR AHASVL