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9.A.48.1.1
The Unconventional Protein Secretion System, UPSS (Giuliani et al., 2011).  Secretes FGF1 and Epimorphin (syntaxin 2) (Hirai et al. 2007)

Accession Number:P97352
Protein Name:S100a13 aka Protein S100-A13
Length:98
Molecular Weight:11158.00
Species:Mus musculus (Mouse) [10090]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate proteins

Cross database links:

Genevestigator: P97352
eggNOG: roNOG17906
HEGENOM: HBG716817
RefSeq: NP_033139.1   
Entrez Gene ID: 20196   
Pfam: PF01023   
KEGG: mmu:20196   

Gene Ontology

GO:0005829 C:cytosol
GO:0005615 C:extracellular space
GO:0005509 F:calcium ion binding
GO:0005507 F:copper ion binding
GO:0008289 F:lipid binding
GO:0050703 P:interleukin-1 alpha secretion

References (8)

[1] “Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family.”  Wicki R.et.al.   8878558
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export.”  Prudovsky I.et.al.   12135982
[4] “S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.”  Mandinova A.et.al.   12746488
[5] “S100A13-lipid interactions-role in the non-classical release of the acidic fibroblast growth factor.”  Kathir K.M.et.al.   17991455
[6] “Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.”  Zanivan S.et.al.   19367708
[7] “Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.”  Landriscina M.et.al.   11432880
[8] “Protein folding does not prevent the nonclassical export of FGF1 and S100A13.”  Graziani I.et.al.   19233122
Structure:
2CXJ     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAETLTELE AAIETVVSTF FTFAGREGRK GSLNINEFKE LATQQLPHLL KDVGSLDEKM 
61:	KTLDVNQDSE LRFSEYWRLI GELAKEVRKE KALGIRKK