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3.D.4.10.2
Bacterial respiratory, anaerobic, nitric oxide reductase (NorBC) (not a proton pump; Flock et al., 2008 )

Accession Number:P98008
Protein Name:NorB
Length:474
Molecular Weight:53137.00
Species:Pseudomonas stutzeri (Pseudomonas perfectomarina) [316]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate H+

Cross database links:

Pfam: PF00115   
BioCyc: MetaCyc:MONOMER-241   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0070469 C:respiratory chain
GO:0009055 F:electron carrier activity
GO:0020037 F:heme binding
GO:0016966 F:nitric oxide reductase activity
GO:0009060 P:aerobic respiration
GO:0022900 P:electron transport chain
GO:0006810 P:transport
GO:0004129 F:cytochrome-c oxidase activity

References (6)

[1] “Nitric oxide reductase from Pseudomonas stutzeri. Primary structure and gene organization of a novel bacterial cytochrome bc complex.”  Zumft W.G.et.al.   7508388
[2] “Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri.”  Heiss B.et.al.   2542222
[3] “The MCD and EPR of the heme centers of nitric oxide reductase from Pseudomonas stutzeri: evidence that the enzyme is structurally related to the heme-copper oxidases.”  Cheesman M.R.et.al.   9521721
[4] “Nitric oxide reductase from Pseudomonas stutzeri. Primary structure and gene organization of a novel bacterial cytochrome bc complex.”  Zumft W.G.et.al.   7508388
[5] “Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri.”  Heiss B.et.al.   2542222
[6] “The MCD and EPR of the heme centers of nitric oxide reductase from Pseudomonas stutzeri: evidence that the enzyme is structurally related to the heme-copper oxidases.”  Cheesman M.R.et.al.   9521721

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSSFNPHLKF QSQAVAKPYF VFALILFVGQ VLFGLIMGLQ YVVGDFLFPL LPFNVARMVH 
61:	TNLLIVWLLF GFMGAAYYLI PEESDCELHS PKLAIILFWV FAAAGVLTIL GYLFVPYAAL 
121:	AEMTRNDLLP TMGREFLEQP TITKIGIVVV ALGFLYNIGM TMLKGRKTVV STVMMTGLIG 
181:	LAVFFLFAFY NPENLSRDKF YWWFVVHLWV EGVWELIMGA MLAFVLIKVT GVDREVIEKW 
241:	LYVIIAMALI TGIIGTGHHF FWIGAPTVWL WVGSIFSALE PLPFFAMVLF ALNMVNRRRR 
301:	EHPNKAASLW AIGTTVTAFL GAGVWGFMHT LAPVNYYTHG SQLTAAHGHL AFYGAYAMIV 
361:	MTMISYAMPR LRGLGEAPDA RAQRIEVWGF WLMTISMIAI TLFLTAAGVV QIWLQRIPAD 
421:	GAAMSFMNTA DQLAIFFWLR FIAGVFFLIG LVCYLYSFRQ RGRVPVVVAA PAAA