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2.A.4.4.1
Heteromeric nuclear/ER Zn2+ uptake permease, Msc2/Zrg17 (Ellis et al., 2005).  Zrg17 is also called Meiotic sister-chromatid recombination-related protein or metal cation transporter Msc2p of 724 aas and 15 TMSs in a 7 + 2 + 6 TMS arrangement.  Only the last 6 TMSs are homologous to CDF transporters.

Accession Number:Q03455
Protein Name:MSC2 aka YD8142.02 aka YDR205W
Length:724
Molecular Weight:80578.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q03455
eggNOG: fuNOG08064
DIP: DIP-5209N
RefSeq: NP_010491.2   
Entrez Gene ID: 851786   
Pfam: PF01545   
KEGG: sce:YDR205W   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0031965 C:nuclear membrane
GO:0005515 F:protein binding
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006882 P:cellular zinc ion homeostasis
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (7)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[2] “Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination.”  Thompson D.A.et.al.   10511544
[3] “The yeast gene MSC2, a member of the cation diffusion facilitator family, affects the cellular distribution of zinc.”  Li L.et.al.   11058603
[4] “Sequencing and comparison of yeast species to identify genes and regulatory elements.”  Kellis M.et.al.   12748633
[5] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[7] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNLQELLAKV PLLLSYPTII LSSNLIVPSH NDLISRAAST SAAEYADEKL IFFSTDHAIR 
61:	LIFLPTFVAS SFNLFAHYFN FINYSSRRKY YVLFTAIYFL SILTAIFHPI QSTCITLLII 
121:	KLLTTADESS PKIALNFKTI LKTFVPFITL TLVILRWDPS FDASSGDVNK ISTSLAAYAL 
181:	LILTLRYASP LILSTLSSSI GVVSKDTSVA QHSISRNKRF PLILVLPIFS FVLLYLMTIV 
241:	NKTYNIQLLM VFVFFGCLSI FFLSLKDLFT EDGNQKKGGQ EDEYCRMFDI KYMISYLWLT 
301:	RFTILLTGIM AIVVHFLSFN EITSSIKTDL LSLLFVVVAE YVSSFSNKQP DSHSHNHAHH 
361:	HSHLTDSLPL ENESMFKQMA LNKDTRSIFS FLLLNTAFMF VQLLYSFRSK SLGLLSDSLH 
421:	MALDCTSLLL GLIAGVLTKK PASDKFPFGL NYLGTLAGFT NGVLLLGIVC GIFVEAIERI 
481:	FNPIHLHATN ELLVVATLGL LVNLVGLFAF DHGAHDHGGT DNENMKGIFL HILADTLGSV 
541:	GVVISTLLIK LTHWPIFDPI ASLLIGSLIL LSALPLLKST SANILLRLDD KKHNLVKSAL 
601:	NQISTTPGIT GYTTPRFWPT ESGSSGHSHA HTHSHAENHS HEHHHDQKNG SQEHPSLVGY 
661:	IHVQYVDGEN STIIKKRVEK IFENVSIKAW VQVEPQNSTC WCRATSMNTI SANPNSLPLQ 
721:	PIAN