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2.A.6.3.10
Multidrug resistance pump, CmeDEF.  The substrates of CmeDEF include ampicillin, ethidium bromide, acridine, sodium dodecyl sulfate (SDS), deoxycholate, triclosan, and cetrimide, but not ciprofloxacin or erythromycin (Pumbwe et al. 2005). This system is similar to the Helicobacter pylori MDR pump, HefABC (Huang et al. 2015).

Accession Number:Q0P9L9
Protein Name:Integral membrane component of efflux system (Multidrug efflux system CmeDEF)
Length:1005
Molecular Weight:111685.00
Species:Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [192222]
Number of TMSs:12
Substrate Ampicillin, ethidium bromide, Acridine, SDS, Deoxycholate, Triclosan, Cetrimide

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFKLAINRPI TVLMFFLALM IFGLISAFSM SVNLFPNVSI PLIKITSKIN GDLNFVESKV 
61:	TKEIENALSE IDGVKTITSA AYDNFSVSVV EFKLGKNLEV AANDVRDKIG TLSLPSKPEI 
121:	EKISSDSGSA ISLFLYSKDK LQLMREINDK IKPFLQRVEG VGKIEAKGFL EPQIRIELKP 
181:	NQLRKYNLNA LDVANIIKSQ NFKQALGELN NNQDNYIIKG YFEATNLEEL SNLRIKTGVF 
241:	LSDIANISSL YEDEKQSALY EGKEGVLLEL GKITNYNTLE MIKNVKNALP ILEKQIPKDI 
301:	SINMLYDKSL NIHKHLSQVI FDMVLGIFLT LVIVFLFLRN LSTTLIACIA IPTSIISTFF 
361:	IIDLLGYDLN RLTFIALTLS IGIFIDDAIV VIENIAKKLK TYPPLQAAFL GINEIGFSVL 
421:	SISIVLLCVF IPISYMNSIS GLFFNALGIS VASGIVISFL VSVFLIPSIG ARFLNPKENK 
481:	FYEKTEAFFE KIEQKYENLL YKILQNKVKF ILATLVFIGL SFALATRIGL DFLPMEDDSE 
541:	IQVLLESKKD LSLEAMKEKS LNLLEKIKND SNVKYAFLLV GYDDAKDATK AKIYVKLKNL 
601:	DERNLRQSAI VSLYRQKFQD ESLKIKILEL PKIEGAGIDD PVQFLILGDD LNTLKEAASQ 
661:	AKEILGTNAR IVDISDNANA TKDEVALHIN KEKAKLLDVN PQYIAGVLGY SFSQLSVGSM 
721:	DRGNSKDDII LSFAPEFKKD IEALKRISIK NNQGINLELS SVVDFIYSKD LKTINRYNKN 
781:	RSVKITAGVN DLSLGAVQKL LLDNMDKILN NNPSLSYAFS GFINLLGETV QGFAMAVALA 
841:	FVLIYLVLAA LYESFILPLI IMITMPLAFG GASIGLFITG HNFSLFVLIA IILLFGMVGK 
901:	NAILLVDVAN KKCHEGLDPD KALLIAGKSR LRAILMTTFA MIFAMLPLAL SRGAGYEANS 
961:	PMAIAIIFGL ISSTLLTLLV VPALFKFCFK LDSKLRKIYE REKLN