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2.A.6.3.10
Multidrug resistance pump, CmeDEF.  The substrates of CmeDEF include ampicillin, ethidium bromide, acridine, sodium dodecyl sulfate (SDS), deoxycholate, triclosan, and cetrimide, but not ciprofloxacin or erythromycin (Pumbwe et al. 2005). This system is similar to the Helicobacter pylori MDR pump, HefABC (Huang et al. 2015).

Accession Number:Q0P9M0
Protein Name:Membrane fusion component of efflux system (Mutlidrug efflux system CmeDEF)
Length:246
Molecular Weight:27778.00
Species:Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [192222]
Substrate Ampicillin, ethidium bromide, Acridine, SDS, Deoxycholate, Triclosan, Cetrimide

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKILFLLLV FNCAFGEEIY ASFNVEASKQ SKLALESIGL VQKIPVEIGQ KVSKGELLLA 
61:	LDQESEKIAL QNAQNSYQLA LVEYENTKSR MQKIKAVENV IDKQSYEDMK AKFDAANLNL 
121:	NKAKINIAYY KNIMAKKELR APYDAIIANK FIQVGEGVGG VAQPLIEIFS YPQSKLILSF 
181:	DEKYKDKVRL GDDFFYKIDQ NGTELKGKIN LIYPSIEVKT RKIYAEVQTT NLTPGLFGEG 
241:	RIITKD