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2.A.6.3.10
Multidrug resistance pump, CmeDEF.  The substrates of CmeDEF include ampicillin, ethidium bromide, acridine, sodium dodecyl sulfate (SDS), deoxycholate, triclosan, and cetrimide, but not ciprofloxacin or erythromycin (Pumbwe et al. 2005). This system is similar to the Helicobacter pylori MDR pump, HefABC (Huang et al. 2015).

Accession Number:Q0P9M1
Protein Name:Outer membrane component of efflux system (Multidrug efflux system CmeDEF)
Length:424
Molecular Weight:48971.00
Species:Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [192222]
Number of TMSs:1
Substrate Ampicillin, ethidium bromide, Acridine, SDS, Deoxycholate, Triclosan, Cetrimide

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFEKYLKSAI FLALYPLAML ASNLHEFIAL SQNNESYLIK QMQSEQANLD KEQAFRNYLP 
61:	SLSLNSAYVA NNKDRFIIDP QESLFAKVSL NFLLFDGGAR EANLRALESR EKLSLLDKEQ 
121:	NKNYLALNAI TLYFNTLSLE KILLANQQKV SFLKSTFERL QKFYDAGLSP KDELESIKAK 
181:	YHLSLLELSQ NELKLANIQK EIKILSDTDF KVQGNAFLEN PQQEKSQNYE VMIAKEQINL 
241:	AKESVNLAKA EYFPKFYIQD NFNFYKNNYN PKVPAPFANL ADQFLEKYSQ GNQFILGMEW 
301:	KIFDFNARAK EVEKERLNVQ IANANARFSE RKNKEELNYL DKSLKVLQEQ ILALNLSLNA 
361:	ANLAFESVDK KYQAGLVSYV EYLQALEVKF KAQSDLELAK NEFEITKANY YFNAGIDLNS 
421:	KVKE