TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.14.10
The heme porter, Shp/SiaABC (HtsABC). Shp is a cell surface heme binding protein that transfers the heme directly to HstA (Nygaard et al., 2006). The crystal structure of the heme binding domain of Shp has been solved (Aranda et al., 2007). HtsABC is required for the uptake of staphyloferrin A (Beasley et al. 2009). The Shp cell surface heme receptor feeds iron-heme to the transporter in preparation for uptake (Sun et al. 2010; Ouattara et al., 2010). 

Accession Number:Q1J548
Protein Name:Putative uncharacterized protein shp
Length:291
Molecular Weight:32404.00
Species:Streptococcus pyogenes serotype M4 (strain MGAS10750) [370554]
Number of TMSs:2
Substrate Heme

Cross database links:

HEGENOM: HBG698455
Entrez Gene ID: 4067389   
Pfam: PF11545   
KEGG: spi:MGAS10750_S   

References (1)

[1] “Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus.”  Beres S.B.et.al.   16636287

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MTKVVIKQLL QVIVVFMISL STMTGVVYAD KGQIYGCIIQ RNYRHPISGQ IEDSGGEHSF 
61:	DIGQGMVEGT VYSDAMLEVS DAGKIVLTFR MSLADYSGNY QFWIQPGGTG SFQAVDYNIT 
121:	QKGTDTNGTA LDIAISLPTV NSIIRGSMFV EPMGREVVFY LSASELIQKY SGNMLAQLVT 
181:	ETDNSQNQEV KDNQKPVDTK LGESQDESHT GAMITQNKPK ANSSNNKSLS DKKILPSKMG 
241:	LTTSLELKKE DKFRSKKDLS IMIYYFPTFF LMLGGFAVWV WKKRKKNDKT M