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2.A.6.1.6
The Zn2+-specific exporter, ZneABC. The ZneB MFP plays an active role in substrate efflux through metal binding and release. Its 2.8 Å structure is available (De Angelis et al., 2010).  3.0 Å  intermediate conformational structures of ZneA have been determined, revealing two Zn2+ binding sites separated by a channel, and the protein has been shown to catalyze electrogenic Zn2+:H+ antiport (Pak et al. 2013).

Accession Number:Q1LCD8
Protein Name:Heavy metal cation tricomponent efflux pump ZneA(CzcA-like)
Length:1039
Molecular Weight:113590.00
Species:Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) [266264]
Number of TMSs:12
Substrate Zn2+, H+

Cross database links:

eggNOG: COG3696
HEGENOM: HBG301912
Entrez Gene ID: 4042190   
Pfam: PF00873   
KEGG: rme:Rmet_5329   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008324 F:cation transmembrane transporter activity
Structure:
4K0E   4K0J     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIERLVTLCF NRRGIVALVF AMVALYGWYA WKQLPLEAYP DIADTTSQVV TQVNGLAAEE 
61:	VEQQITIPLE REIMGVPGMH VMRSKSTFGL SLITVVFKDG AEDYWSRQRL QERINGVSLP 
121:	YGAQPSLDPL TSPIGEIYRY TLVSKTRDLR ELSELQFWKV IPRLKQVAGV VDVANFGGLT 
181:	TQFMLEFDPV MLSKYNISLN QITQAISENN ANAGGSILNR GEQGLVVRGV GLIRNLDDLG 
241:	NIVVTQKNGV PVLVKDLGRV VLGNPQRHGI LGMDRNPDTI QGITLLLKNE NPSVVMEGVH 
301:	AAVRDLNDNI LPKDVKVVPY IDRSNLVDAT VHTVGKTLME GMFLVSLVLL LFLGSPRAAI 
361:	IVAVTIPLSL LMAFILMHHF KIPANLLSLG AIDFGIIVDG AIVVMENILR RREEDAEKEL 
421:	HGRDIMQSVL QVARPIFFGM IVIITAYLPL FAFQRIEYKL FSPMAFAVGF ALFGALLVAL 
481:	LLIPGLAYWA YRKPRKVFHN PALVWLAPRY ESVLNRLVGS TRTAIGIAVA TLVGVMILGA 
541:	TIGRDFLPYL DEGSIWLQVT LPPGISLEKA GQMADNLRAA TMEFPEVEHV VTQVGRNDEG 
601:	TDPFSPSHIE TAVTLHPYST WTSGRDKQQL IEAMATRFRD LPGTQVGFSQ PMIDGVLDKL 
661:	AGAHSDLVVK VYGNDFAETR QVATAITRLL KTVPGAQDVI IDQEPPLPQV RIDVDRAAAA 
721:	RLGINVADVM ALIQTGIGGS PVTQVFVEDR SYNVVARFIG SSRNDPEAIG NLTLTAANGA 
781:	HVALAQVAHI RLAEGETTIT REMNKRHLTV RLNLRGRDLS TFLEEARMRI DKEVPYDRTH 
841:	IQVAWGGQFE NQQRAQARLA VILPMVLALM FVLLFGEFKN LRQPALILMA VPLATLGGLV 
901:	ALHLRGMTLN VSSAVGFIAL FGVAVLNAII MIANLNRWRD TSGVSLKEAV VRGAGERMRP 
961:	VLMTATVAAL GLIPAALAHG LGSDVQRPLA TVVVGGLITA TALTLVLLPA LYYLIETRAA 
1021:	KQVREEPPVQ FGPTSEGDL