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4.A.2.1.9
The FrzABC PTS putative transporter (promotes bacterial fitness under stress conditions and promotes fimbrial (fim) gene expression indirectly (Rouquet et al., 2009). Might transport D-tagatose, D-psicose and/or D-sorbose, or a disaccharide of these (Rouquet et al. 2009); involved in environmental sensing, host adaptation and virulence (Patron et al. 2015).

Accession Number:Q1R4T1
Protein Name:Putative PTS enzyme-II fructose
Length:363
Molecular Weight:38795.00
Species:Escherichia coli (strain UTI89 / UPEC) [364106]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Tagatose, psicose, Sorbose

Cross database links:

eggNOG: COG1299
HEGENOM: HBG704192
RefSeq: YP_543164.1   
Entrez Gene ID: 3991482   
Pfam: PF02378   
BioCyc: ECOL364106:UTI89_C4205-MONOMER   
KEGG: eci:UTI89_C4205   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (1)

[1] “Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach.”  Chen S.L.et.al.   16585510

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKENKIPVSQ EIKKHLLTGI SWMIPLIVAA GICIALGQVL GGTDVGEKTG TIPWMLNQIG 
61:	GWGMGLIVPL ISAAIAYSIA DRPGFAPGLI VGFLCGQIHT GFIGGMLGGF LVGYTILLLK 
121:	RYIRLPQSMQ GLMPIMVLPV LSTIIGGLLM MTLIGKPIAW LQEALIHLLE SMQGGSRFLM 
181:	GAILGAMATF DFGGPVNKTM SLFSDGLLVS GVYGPEAVKF VGSIIPPFGI TLSFLLTRHK 
241:	YTRAEREALK AAFPMGICMI TEGVIPIAAR DLLRVVGSCV VASAVAGGLI MVWGVESPVP 
301:	HGGMFVVPLF THPLLFCLAL GIGTVICGVM LSLWKKPVTE RDEEFDELSD QKLKDEEITF 
361:	TLE