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1.A.9.5.6
Gamma-aminobutyric acid receptor, LCCH3 of 496 aas and 4 TMSs/ GRD of 686 aas and 4 TMSs.  LCCH3 combines with the ligand-gated ion channel subunit, GRD, to form cation-selective GABA-gated ion channels.  The heteromultimeric receptor is activated by GABA (EC50=4.5 microm), muscimol (EC50=4.8 microm) and trans-4-aminocrotonic acid (EC50=104.5 microm), and partially by cis-4-aminocrotonic acid (EC50=106.3 microm). Picrotoxin effectively blocked the GABA-gated channel (IC50=0.25 microm), but bicuculline, TPMTA, dieldrin and lindane did not. The benzodiazepines flunitrazepam and diazepam did not potentiate the GABA-evoked current (Gisselmann et al. 2004). The system has been partially characterized from the small brown planthopper, Laodelphax striatellus (Fallen), a major insect pest of crop systems in East Asia (Wei et al. 2017).

Accession Number:Q24352
Protein Name:Gamma-aminobutyric acid receptor alpha-like
Length:686
Molecular Weight:76558.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate inorganic cations

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MCTMPATRDA SGSGDASTDL IAARSLSSHQ GQRSNLRIFK LLISCCLLML CIYPNAWPWS 
61:	IGPGSGPFSV SADSIKGRGD THRLGEMGTS LSSSLPSSWL TQSNNHANIS ELLDNLLRGY 
121:	DNSIRPDFGG PPATIEVDIM VRSMGPISEV DMTYSMDCYF RQSWVDKRLA FEGAQDTLAL 
181:	SVSMLARIWK PDTYFYNGKQ SYLHTITTPN KFVRIYQNGR VLYSSRLTIK AGCPMNLADF 
241:	PMDIQKCPLK FGSFGYTTSD VIYRWNKERP PVAIAEDMKL SQFDLVDCPA GNLTDIVYKA 
301:	AAPRPQRRPF NNKDPPRPTS KVMTTFAGPA AKNQHVRGTG LKLDKGAFGT GRDATGGSGS 
361:	TTGLSGTITL ETNHPSEYSM LMVNFHLQRH MGNFLIQVYG PCCLLVVLSW VSFWLNREAT 
421:	ADRVSLGITT VLTMTFLGLE ARTDLPKVSY PTALDFFVFL SFGFIFATIL QFAVVHYYTK 
481:	YGSGECYFII EELDSESGES ETEPLTSDFR GSTESKIYEV IPLSMCAISM PPPPTRLGML 
541:	TSRNRRPRNR RHGLWSMKLL GLFDWRRRRK PPRADSDEDE DDEQTQLRAN EAPTTSAAAA 
601:	AAQAAAQAAR ISPPTGGRRR MSYYRREEME ARRKGKRTPQ YNSVSKIDRA SRIVFPLLFI 
661:	LINVFYWYGY LSRSSRILAN TPDAST