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2.A.6.2.29
The AdeIJK MDR pump (contributes to resistance to β-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim, acridine, safranin, pyronine, triclosan and sodium dodecyl sulfate) (Damier-Piolle et al., 2008; Fernando et al. 2014Fernando et al. 2014)

Accession Number:Q24LT6
Protein Name:AdeK
Length:484
Molecular Weight:52802.00
Species:Acinetobacter baumannii [470]
Location1 / Topology2 / Orientation3: Secreted1
Substrate Beta-lactams, Chloramphenicol, tetracycline, erythromycin, Lincosamide, Fluoroquinolones, Fusidic acid, Tigecycline, Novobiocin, Rifampin, Trimethoprim, Acridine, Safranin, Pyronine, Triclosan, SDS

Cross database links:

Pfam: PF02321   

Gene Ontology

GO:0016020 C:membrane
GO:0008289 F:lipid binding
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in Acinetobacter baumannii.”  Damier-Piolle L.et.al.   18086852

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQKVWSISGR SIAVSALALA LAACQSMRGP EPVVKTDIPQ SYAYNSASGT SIAEQGYKQF 
61:	FADPRLLEVI DLALANNRDL RTATLNIERA QQQYQITQNN QLPTIGASGS AIRQVSQSRD 
121:	PNNPYSTYQV GLGVTAYELD FWGRVRSLKD AALDSYLATQ SARDSTQISL ISQVAQAWLN 
181:	YSFATANLRL AEQTLKAQLD SYNLNKKRFD VGIDSEVPLR QAQISVETAR NDVANYKTQI 
241:	AQAQNLLNLL VGQPVPQNLL PTQPVKRIAQ QNVFTAGLPS DLLNNRPDVK AAEYNLSAAG 
301:	ANIGAAKARL FPTISLTGSA GYASTDLSDL FKSGGFVWSV GPSLDLPIFD WGTRRANVKI 
361:	SETDQKIALS DYEKSVQSAF REVNDALATR ANIGERLTAQ QRLVEATNRN YTLSNARFRA 
421:	GIDSYLTVLD AQRSSYAAEQ GLLLLQQANL NNQIELYKTL GGGLKANTSD TVVHQPSSAE 
481:	LKKQ