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2.A.6.2.29
The AdeIJK MDR pump (contributes to resistance to β-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim, acridine, safranin, pyronine, triclosan and sodium dodecyl sulfate) (Damier-Piolle et al., 2008; Fernando et al. 2014Fernando et al. 2014)

Accession Number:Q24LT7
Protein Name:AdeJ
Length:1058
Molecular Weight:114569.00
Species:Acinetobacter baumannii [470]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Secreted1
Substrate Beta-lactams, Chloramphenicol, tetracycline, erythromycin, Lincosamide, Fluoroquinolones, Fusidic acid, Tigecycline, Novobiocin, Rifampin, Trimethoprim, Acridine, Safranin, Pyronine, Triclosan, SDS

Cross database links:

Pfam: PF00873   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in Acinetobacter baumannii.”  Damier-Piolle L.et.al.   18086852

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MAQFFIHRPI FAWVIALVIM LAGILTLTKM PIAQYPTIAP PTVTIAATYP GASAETVENT 
61:	VTQIIEQQMN GLDGLRYISS NSAGNGQASI QLNFEQGVDP DIAQVQVQNK LQSATALLPE 
121:	DVQRQGVTVT KSGASFLQVI AFYSPDNNLS DSDIKDYVNS SIKEPLSRVA GVGEVQVFGG 
181:	SYAMRIWLDP AKLTSYQLTP SDIATALQAQ NSQVAVGQLG GAPAVQGQVL NATVNAQSLL 
241:	QTPEQFKNIF LKNTASGAEV RLKDVARVEL GSDNYQFDSK FNGKPAAGLA IKIATGANAL 
301:	DTAEAVEQRL SELRKNYPTG LADKLAYDTT PFIRLSIESV VHTLIEAVIL VFIVMFLFLQ 
361:	NWRATIIPTL AVPVVVLGTF AVINIFGFSI NTLTMFAMVL AIGLLVDDAI VVVENVERVM 
421:	SEDHTDPVTA TSRSMQQISG ALVGITSVLT AVFVPMAFFG GTTGVIYRQF SITLVTAMVL 
481:	SLIVALTFTP ALCATILKQH DPNKEPSNNI FARFFRSFNN GFDRMSHSYQ NGVSRMLKGK 
541:	IFSGVLYAVV VALLVFLFQK LPSSFLPEED QGVVMTLVQL PPNATLDRTG KVIDTMTNFF 
601:	MNEKDTVESI FTVSGFSFTG VGQNAGIGFV KLKDWSKRTT PETQIGSLIQ RGMALNMIIK 
661:	DASYVMPLQL PAMPELGVTA GFNLQLKDSS GQGHEKLIAA RNTILGLASQ DKRLVGVRPN 
721:	GQEDTPQYQI NVDQAQAGAM GVSIAEINNT MRIAWGGSYI NDFVDRGRVK KVYVQGDAGS 
781:	RMMPEDLNKW YVRNNKGEMV PFSAFATGEW TYGSPRLERY NGVSSVNIQG TPAPGVSSGD 
841:	AMKAMEEIIG KLPSMGLQGF DYEWTGLSLE ERESGAQAPF LYALSLLIVF LCLAALYESW 
901:	SIPFSVLLVV PLGVIGAIVL TYLGMIIKGD PNLSNNIYFQ VAIIAVIGLS AKNAILIVEF 
961:	AKELQEKGED LLDATLHAAK MRLRPIIMTT LAFGFGVLPL ALSTGAGAGS QHSVGFGVLG 
1021:	GVLSATFLGI FFIPVFYVWI RSMFKYKPKT INTQEHKS