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1.A.6.2.2
Touch-responsive mechanosensitive degenerin channel complex (Mec-4/Mec-10 form the cation/Ca2+-permeable channel; Mec-2 and Mec-6 regulate) (Bianchi, 2007; Chelur et al., 2002; ). Mec-6 is a chaparone protein required for functional insertion (Matthewman et al. 2018). Mec-10 plays a role in the response to mechanical forces such as laminar shear stress (Shi et al. 2016). MEC-4 or MEC-10 mutants that alter the channel's LSS response are primarily clustered between the degenerin site and the selectivity filter, a region that likely forms the narrowest portion of the channel pore (Shi et al. 2018). TMS2 forms the Ca2+ channel of Mec-4.  A C-terminal domain affects trafficking of a neuronally expressed DEG/ENaC. Neuronal swelling occurs prior to commitment to necrotic death (Royal et al. 2005).

Accession Number:Q27433
Protein Name:Mec-2
Length:481
Molecular Weight:51900.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass membrane protein2
Substrate Na+

Cross database links:

eggNOG: meNOG06651
HEGENOM: HBG714701
RefSeq: NP_741797.1   
Entrez Gene ID: 180826   
Pfam: PF01145   

Gene Ontology

GO:0016021 C:integral to membrane

References (3)

[1] “A stomatin-like protein necessary for mechanosensation in C. elegans.”  Huang M.et.al.   7477350
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel.”  Chelur D.S.et.al.   12478294

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSATMSSARN SVVSLSSNGS VKVETRLVSN ERSSSIQQEG AMLPSSSSKD DDLLSTSSDE 
61:	VENMATRTLQ QLEESTSIIS ANSDDDSVKK EKQAEKDVEK GNGKEEKANI QNEFGVCGWI 
121:	LTILSYLLIF FTLPISACMC IKVVQEYERA VIFRLGRLMP GGAKGPGIFF IVPCIDTYRK 
181:	VDLRVLSFEV PPQEILSKDS VTVAVDAVVY FRISNATISV TNVEDAARST KLLAQTTLRN 
241:	ILGTKTLAEM LSDREAISHQ MQTTLDEATE PWGVKVERVE VKDVRLPVQL QRAMAAEAEA 
301:	AREARAKVIV AEGEQKASRA LKEAAEVIAE SPSALQLRYL QTLNSISAEK NSTIIFPFPI 
361:	DLLSAFLQRT PPKVEEPPSL PKKIRSCCLY KYPDWVQGMV GSEGGGGHGH SHGGGGGGLG 
421:	SSQGAFHPSQ AGSGPSTTTT SGRPLLRSMR EAQFHSAAPP ISAPNQSQTS VSQLDPALLI 
481:	R