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2.A.6.2.26
The multidrug efflux pump, VmeAB-VpoC (Matsuo et al., 2007).  There are 11 RND-type efflux transporters in Vibrio parahaemolyticus, and several (VmeCD, VmeEF and VmeYZ) contribute not only to intrinsic drug resistance but also to virulence (Matsuo et al. 2013).

Accession Number:Q2AAU3
Protein Name:VmeB
Length:1053
Molecular Weight:113402.00
Species:Vibrio parahaemolyticus [670]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Secreted1
Substrate drugs

Cross database links:

Pfam: PF00873   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MARFFIDRPV FAWVLAILTM LAGIMSLFNL PVSQYPTISP TTITISARYP GASAKTVEDS 
61:	VTQVIEQNMT GLDYLRYLSS SSDAFGNATI TLTFDSEADP DIAQVQVQNK LQLALTSLPM 
121:	EVQSQGIVVN KSNTSFLMVV AVYSDDPDFT QNDIADFVVT NIQDPISRVT GVGQVQAFGS 
181:	QYAMRVWLDP FKLTQFNLTA IDVANAISEQ NAQVSSGQLG AAPAQKGQLL NATISSASRL 
241:	SSVAEFQNII LKSDASGANV YLRDVARIER GAESYDIQGQ YNGLPASGLG ISLGTGANAL 
301:	ETAAAVKERL AELSENFPDG LKVAYPFETT PFVEASIQEV VKTLLEAIVL VFLIMYLFLQ 
361:	NFRATIIPTI AVPVVLLGTF AILYATGFSV NTLTMFAMVL AIGLLVDDAI VVVENVERVM 
421:	HEDGLDPKEA TKKSMGQITG ALIGVGLTLS AVFVPMAFMS GSTGVIYRQF SITIVAAMTL 
481:	SVMVAIILTP ALCATLLKKG DAEFTDKKGF FGWFNRKFDS MTAGYEAGVA KLLKRTGRML 
541:	LVFVAMSAGA GWLFMNLPTS FLPDEDQGTV FSMAILPPNS TQEQTEKTLD KVRSYFLEEE 
601:	KDNVRSVFTV AGFSFAGQGQ NMGMAFIGLK DWSEREAPGS DAASLTGRAM GYFSTIKEAM 
661:	VFAFAPPAIQ ELGNATGFDF YLQDSLSLGH EALVAAQGQL LGMAAQNPKL VGVRPNGQSD 
721:	APMYQVHVDH VKLRALDVSI NDVNQILSAA WGGAYINDYI DRGRVKKVMV QSDAEFRMQP 
781:	EDFNSWYVRN AQGEMVPFSA FASGEWTYGS PQLQRFNGLA AMNIQGGAAP GVSTGEAMAE 
841:	IEAMVEQLPE GFTVNWNGIS YEERLSGNQA PMLYALSILV VFLVLAALYE SWSVPLAVVL 
901:	VVPLGVLGAV LAVLGRGMDN DVFFQVSLLT TVGLATKNAI LIVEFAKEYY EKGAGLIEAT 
961:	LHAVRVRLRP IIMTSLAFGL GVVPLAISAG VGSAGQNAVG TGVLGGMISA TLLGIFFVPV 
1021:	FFVVVERLFD RRAQKEAQKE RSQELDPATE KSE