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2.A.6.2.44
Multidrug efflux pump, AdeFGH.  Mediates high level resistance to chloramphenicol, clindamycin, fluoroquinolones, and trimethoprim and decreased susceptibility to tetracycline-tigecycline and sulfonamides; susceptibility to β-lactams, erythromycin, aminoglycosides and rifampin was not affected. It also mediates increased resistance to ethidium bromide, safranin O, acridine orange, trimethoprim and sulfamethoxazole (Coyne et al. 2010).

Accession Number:Q2FD80
Protein Name:Putative RND family drug transporter
Length:483
Molecular Weight:52465.00
Species:Acinetobacter baumannii [470]
Number of TMSs:1
Substrate Chloramphenicol, Clindamycin, Fluoroquinolones, Trimethoprim, Tetracycline-tigecycline, Sulfonamides, ethidium bromide, safranin O, Acridine orange, Sulfamethoxazole

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVITSKQNWL LSSLMGSLLL AGCSLAPEYQ PAKVIVPVKF KESDPKLEDN NWKIAQPADQ 
61:	QTRGEWWRIY NDAQLNELEQ QAIAGNQNLK AVAANIQASR ALRSAAQAER LPSIDAGFGP 
121:	TRQKPSPASL GLDDNAHTSA QTLWRAQANV SYELDLFGRV ASSVNAATAD LQQQEALYQS 
181:	ALLALQADVA QGYFLIRQLD TEQAIYNRTI KLLGETRDLM QLRFKNGLVS ELDVSRAQTE 
241:	LATAQTTALN IARNRASAEH ALAVLLGKPP ADFNLAVQPL TANSIRLPAG LPSTLLERRP 
301:	DIAAAERAMA ADNARIGIAR AAFFPKLSLT GALGYESSSL SELGKWSSRT FLLGPVAGTI 
361:	LSLPLFDGGQ RKAGVAQARA AYEESVANYR QTVLNAFREV ENGLSDQRIL DQQIQAQNQA 
421:	LSSSRHANQL SHLRYREGAI SYLDVIDSDR TILQQEQLAA QLKGSQIIAS INLIRALGGG 
481:	WSS