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2.A.6.2.44
Multidrug efflux pump, AdeFGH.  Mediates high level resistance to chloramphenicol, clindamycin, fluoroquinolones, and trimethoprim and decreased susceptibility to tetracycline-tigecycline and sulfonamides; susceptibility to β-lactams, erythromycin, aminoglycosides and rifampin was not affected. It also mediates increased resistance to ethidium bromide, safranin O, acridine orange, trimethoprim and sulfamethoxazole (Coyne et al. 2010).

Accession Number:Q2FD81
Protein Name:Cation/multidrug efflux pump
Length:1059
Molecular Weight:114214.00
Species:Acinetobacter baumannii [470]
Number of TMSs:12
Substrate Chloramphenicol, Clindamycin, Fluoroquinolones, Trimethoprim, Tetracycline-tigecycline, Sulfonamides, ethidium bromide, safranin O, Acridine orange, Sulfamethoxazole

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNISKFFIDR PIFAGVLSVL ILLAGLLSVF QLPISEYPEV VPPSVVVRAQ YPGANPKVIA 
61:	ETVASPLEES INGVEDMLYM QSQANSDGNL TITVNFKLGI DPDKAQQLVQ NRVSQAMPRL 
121:	PEDVQRLGVT TLKSSPTLTM VVHLTSPDNR YDMTYLRNYA VLNVKDRLAR LQGVGEVGLF 
181:	GSGDYAMRVW LDPQKVAQRN LTATEIVNAI REQNIQVAAG TIGASPSNSP LQLSVNAQGR 
241:	LTTEQEFADI ILKTAPDGAV TRLGDVARVE LAASQYGLRS LLDNKQAVAI PIFQAPGANA 
301:	LQVSDQVRST MKELSKDFPS SIKYDIVYDP TQFVRASIKA VVHTLLEAIT LVVVVVILFL 
361:	QTWRASIIPL LAVPVSIIGT FALMLAFGYS INALSLFGMV LAIGIVVDDA IVVVENVERN 
421:	IEAGLNPREA TYRAMREVSG PIIAIALTLV AVFVPLAFMT GLTGQFYKQF AMTIAISTVI 
481:	SAFNSLTLSP ALAALLLKGH DAKPDALTRI MNRVFGRFFA LFNRVFSRAS DRYSQGVSRV 
541:	ISHKASAMGV YAALLGLTVG ISYIVPGGFV PAQDKQYLIS FAQLPNGASL DRTEAVIRKM 
601:	SDTALKQPGV ESAVAFPGLS INGFTNSSSA GIVFVTLKPF DERKAKDLSA NAIAGALNQK 
661:	YSAIQDAYIA VFPPPPVMGL GTMGGFKLQL EDRGALGYSA LNDAAQNFMK AAQSAPELGP 
721:	MFSSYQINVP QLNVDLDRVK AKQQGVAVTD VFNTMQIYLG SQYVNDFNRF GRVYQVRAQA 
781:	DAPFRANPED ILQLKTRNSA GQMVPLSSLV NVTQTYGPEM VVRYNGYTSA DINGGPAPGY 
841:	SSSQAEAAVE RIAAQTLPRG IKFEWTDLTY QKILAGNAGL WVFPISVLLV FLVLAAQYES 
901:	LTLPLAVILI VPMGILAALT GVWLTAGDNN IFTQIGLMVL VGLACKNAIL IVEFARELEM 
961:	QGATAFKAAV EASRLRLRPI LMTSIAFIMG VVPLVTSTGA GSEMRHAMGV AVFFGMIGVT 
1021:	FFGLFLTPAF YVLIRTLNSK HKLHSAAVHE APLASPHDH