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2.A.6.2.29
The AdeIJK MDR pump (contributes to resistance to β-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim, acridine, safranin, pyronine, triclosan and sodium dodecyl sulfate) (Damier-Piolle et al., 2008; Fernando et al. 2014Fernando et al. 2014)

Accession Number:Q2FD95
Protein Name:AdeI
Length:416
Molecular Weight:43806.00
Species:Acinetobacter baumannii [470]
Location1 / Topology2 / Orientation3: Secreted1
Substrate Beta-lactams, Chloramphenicol, tetracycline, erythromycin, Lincosamide, Fluoroquinolones, Fusidic acid, Tigecycline, Novobiocin, Rifampin, Trimethoprim, Acridine, Safranin, Pyronine, Triclosan, SDS

Cross database links:

Pfam: PF00529   

Gene Ontology

GO:0016020 C:membrane
GO:0008565 F:protein transporter activity
GO:0009306 P:protein secretion

References (1)

[1] “AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in Acinetobacter baumannii.”  Damier-Piolle L.et.al.   18086852

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMSAKLWAPA LTACALATSI ALVGCSKGSD EKQQAAAAQK MPPAEVGVIV AQPQSVEQSV 
61:	ELSGRTSAYQ ISEVRPQTSG VILKRLFAEG SYVREGQALY ELDSRTNRAT LENAKASLLQ 
121:	QQANLASLRT KLNRYKQLVS SNAVSKQEYD DLLGQVNVAE AQVAAAKAQV TNANVDLGYS 
181:	TIRSPISGQS GRSSVTAGAL VTANQTDPLV TIQQLDPIYV DINQSSAELL RLRQQLSKGS 
241:	LNNSNNTKVK LKLEDGSTYP IEGQLAFSDA SVNQDTGTIT LRAVFSNPNH LLLPGMYTTA 
301:	QIVQGVVPNA YLIPQAAITR LPTGQAVAML VNAKGVVESR PVETSGVQGQ NWIVTNGLKA 
361:	GDKVIVDGVA KVKEGQEVSA KPYQAQPANS QGAAPNAAKP AQSGKPQAEQ KAASNA