TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.77.1.7
Mitochondrial Ca2+ Uniporter, a channel complex. MCU is a putative 5TMS protein (307 aas) with homology to MCU Ca2+/Mg2+ channels in the C-terminal 2TMS domain. The N-terminal domain is found only in Trypanosoma and Leishmania species. The TbMCU complex possesses four subunits, MCU (307 aas), MCUb (214 aas), MCUc (254 aas) and MCUd (249 aas)), present only in trypanosomatids and required for Ca2+ transport. These four subunits  interact through their transmembrane helices to form hetero-oligomers in a ~380 KDa complex (Huang and Docampo 2018).

Accession Number:Q38C29
Protein Name:Uncharacterized protein
Length:214
Molecular Weight:24719.00
Species:Trypanosoma brucei brucei (strain 927/4 GUTat10.1) [185431]
Number of TMSs:2
Substrate Mg2+, Ca2+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVGTVLRVYT HRTRCIGELC SVAPLCVILE QRRPGPSFGI RSQSREDNSV HFLPCEGAVD 
61:	LSLRALSTIE GLRNYREHRL RPQLLVKRAE LRQADDVKTR CDALGLRYAD RCIAIAVALI 
121:	LIRNVVLFYW VYFLFDWNLV EPITYLLERG AVCLGFLWYG ATSSDARFES FRQFLVSRRT 
181:	QRLYAQHNFN AGHWKELVVE VEGLEEQLRG LETV