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2.A.6.2.34
Multidrug efflux pump, MexPQ-OpmE; export fluoroquinolones, tetracycline, macrolides and chloramphenicol (Poole, 2008)

Accession Number:Q4LDT6
Protein Name:MexQ
Length:1053
Molecular Weight:112308.00
Species:Pseudomonas aeruginosa GN=mexQ PE=4 SV=1 [287]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Virion membrane1 / Single-pass type I membrane protein2
Substrate Fluoroquinolones, tetracycline, Macrolides, Chloramphenicol

Cross database links:

Pfam: PF00873   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa.”  Mima T.et.al.   16301811

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTFPRFFIDR PIFAIVLSVL MMIGGIVSFF QLPLSEYPAV TPPTVQVTTA YPGANPDVIA 
61:	QTVATPLEQA ITGVEGMLYM SSQSATDGRM ILTITFDQHI DPDMAQIQVQ NRVSRVLSRL 
121:	PDEVQRQGVV TQKTSPDILM VVHLLSPEQR YDPLYISNYA YLQVRDELLR LPGISDVVVW 
181:	GAGEYSMRLW LDPDLIAARG LTAGEVIAAV REQNVQVAAG AVGQAPDSTA AFQVTVNTLG 
241:	RLSDEEQFGD IIVRTGADGQ VTRLRDVARI EMGGDAYALR SLLDGEPAVA LQIIQSPGAN 
301:	ALDTAEAVRA TVARLEGNFP AGLSARIAYD PTVFVRASLQ TVATTLLEAI LLVVVVVVLF 
361:	LRSWRASLIP LMAVPVSLVG TFAVMHLMGF SLNTLSLFGL VLSIGIVVDD AIVVVENVER 
421:	HIENGEPPLQ AARRAMDEVT GPIMAITSVL AAVFIPTAFL SGLQGEFYRQ FALTIAISTI 
481:	LSALNSLTLS PALAGLLLRP RPAGGAVAGR FQRLLQVLGR PLRNAPEAYG NAVRKVVRVS 
541:	GLALVVYGGL LGLTWVGFQA VPPGFVPMQD KYYLIGIAQL PNGASLERTD AVVRQMSRIG 
601:	LDEPGVESVV AFPGLSVNGF VNVPNAAVMF FMLDPFESRT SADLGALAIA GRLQARFASI 
661:	PDGFLGVFPP PPVPGLGTIG GFKMQVEDRG GAGLEALARQ TQVLMMKATE SGQLGGLMTS 
721:	FDINAPQLEV VVDRTKVKSQ GVRLADVFEA LQVYLGSLYI NDFNRFGRTY KVTAQADAPH 
781:	RMQAEAIGRL QVRNAAGAML PLSSFVTVTP SSGPDRVIHY NGYPSADISG GALPGVSSGQ 
841:	AVALMERLAG EVLPEGMTFE WTDLTYQQKL AGNSALFIFP LCVLLAYLIL AAQYNSWLLP 
901:	LAVLLIVPMC LLSAIAGVWL VGGDNNVFVQ IGLVVLVGLA AKNAILIVEF ARTLEAEGAR 
961:	ALEAVVEACR LRLRPILMTS LAFIAGVVPL VMASGAGAEM RQAMGVAVFA GMLGVTLFGL 
1021:	FLTPVFYVLV RALAARLERR AGGSLAHLEG GRP