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9.A.39.1.2
Iron regulated surface determinant, Haptoglobin receptor A (HarA or IsdH) precursor (891 aas). Also binds hemoglobin and haptoglobin/hemoglobin complexes with nM or µM binding constants to an 8-stranded anti-parallel β-barrel domain (Dryla et al., 2007). The functionally distinct NEAT (NEAr Transporter) domain within IsdH extracts heme from methemoglobin (Pilpa et al., 2009). Hemoglobin/myoglobin receptor B (IsdB), transferrin, hemin, fetuin, asialofetuin receptor (IsdA), and the cell wall conduit, IsdC may comprise the full system (Villareal et al., 2008).

Accession Number:Q6GHV7
Protein Name:Iron-regulated surface determinant protein B aka IsdB
Length:652
Molecular Weight:72999.00
Species:Staphylococcus aureus (strain MRSA252) [282458]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1 / Peptidoglycan-anchor2
Substrate iron-heme complex

Cross database links:

HEGENOM: HBG215818 HBG215818
RefSeq: YP_040515.1   
Entrez Gene ID: 2859674   
Pfam: PF00746    PF05031    PF04650   
BioCyc: SAUR282458:SAR1102-MONOMER   
KEGG: sar:SAR1102    sar:SAR1102   

Gene Ontology

GO:0009986 C:cell surface
GO:0005618 C:cell wall
GO:0005576 C:extracellular region
GO:0016020 C:membrane
GO:0046872 F:metal ion binding
GO:0009405 P:pathogenesis

References (4)

[1] “Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.”  Holden M.T.G.et.al.   15213324
[2] “Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus.”  Palazzolo-Ballance A.M.et.al.   18097052
[3] “Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.”  Holden M.T.G.et.al.   15213324
[4] “Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus.”  Palazzolo-Ballance A.M.et.al.   18097052

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKQQKEFKS FYSIRKSSLG VASVAISTLL LLMSNGEAKA AEETGVTNTE AQPKTEAVAS 
61:	PTTTTTEKAP EAKPVAKPVA NAVSVSNKEV VAPTTETKEA KEVKAVKEVK APKEAKEEKP 
121:	AAKADNNTYP ILNQELREAI KNPAIKDKDH SAPNSRPIDF EMKKKDGTQQ FYHYASSVKP 
181:	ARVIFTDSKP EIELGLQSGQ FWRKFEVYEG DKKLPIKLVS YDTVKDYAYI RFSVSNGTKA 
241:	VKIVSSTHFN NKEEKYDYTL MEFAQPIYNS ADKFKTEEDY KAEKLLAPYK KAKTLERQVY 
301:	ELNKIQDKLP EKLKAEYKKK LEETKKALDE QVKSAITEFQ NVQPTNEKMT DLQDTKYVVY 
361:	ESVENNESMM DAFVKHPIKT GMLNGKKYMV METTNDDYWK DFMVEGQRVR TISKDAKNNT 
421:	RTIIFPYVEG KTLYDAIVKV HVKTIDYDGQ YHVRIVDKEA FTKANADKTN KKEQQDNSAK 
481:	KETTPAMPSK PTTPPVEKES QKQDSQKDDN KQSPSVEKEN DASSESGKDK MPVTKPAKAE 
541:	VESSSTTPTK VVSTTQNVAK PTTASSETTK DVVQTSAGSS EAKDSAPLQK ANIKNTNDGH 
601:	TQSQNNKNTQ ENKAKSLPQT GEESNKDMTL PLMALIALSS IVAFVLPRKR KN