TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.14.17
Heme acquisition ABC uptake transporter, IsdDEF (Liu et al., 2008)

Accession Number:Q7A652
Protein Name:IsdE
Length:292
Molecular Weight:33271.00
Species:Staphylococcus aureus (strain N315) [158879]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Lipid-anchor2
Substrate Heme

Cross database links:

eggNOG: COG0614
HEGENOM: HBG306131
RefSeq: NP_374250.1   
Entrez Gene ID: 1123807   
Pfam: PF01497   
BioCyc: SAUR158879:SA0980-MONOMER   
KEGG: sau:SA0980   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005381 F:iron ion transmembrane transporter activity
GO:0046872 F:metal ion binding
GO:0006827 P:high-affinity iron ion transport

References (2)

[1] “Whole genome sequencing of meticillin-resistant Staphylococcus aureus.”  Kuroda M.et.al.   11418146
[2] “Heme coordination by Staphylococcus aureus IsdE.”  Grigg J.C.et.al.   17666394
Structure:
2Q8P   2Q8Q     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRIIKYLTIL VISVVILTSC QSSSSQESTK SGEFRIVPTT VALTMTLDKL DLPIVGKPTS 
61:	YKTLPNRYKD VPEIGQPMEP NVEAVKKLKP THVLSVSTIK DEMQPFYKQL NMKGYFYDFD 
121:	SLKGMQKSIT QLGDQFNRKA QAKELNDHLN SVKQKIENKA AKQKKHPKVL ILMGVPGSYL 
181:	VATDKSYIGD LVKIAGGENV IKVKDRQYIS SNTENLLNIN PDIILRLPHG MPEEVKKMFQ 
241:	KEFKQNDIWK HFKAVKNNHV YDLEEVPFGI TANVDADKAM TQLYDLFYKD KK