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3.A.1.12.13
High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7)

Accession Number:Q7CXG0
Protein Name:ABC transporter, substrate binding protein (Proline/glycine betaine)
Length:317
Molecular Weight:33913.00
Species:Agrobacterium tumefaciens (strain C58 / ATCC 33970) [176299]
Number of TMSs:1
Substrate Choline

Cross database links:

eggNOG: COG2113
HEGENOM: HBG696360
Entrez Gene ID: 1134319   
Pfam: PF04069   
KEGG: atu:Atu2281   

Gene Ontology

GO:0005488 F:binding
GO:0005215 F:transporter activity

References (2)

[1] “Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.”  Goodner B.et.al.   11743194
[2] “The genome of the natural genetic engineer Agrobacterium tumefaciens C58.”  Wood D.W.et.al.   11743193

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFANRSRCLA LAAAISSMTF SAAVAAEPAS CGTVRFSDVG WTDITATTAT ATVLLKSLGY 
61:	ETDVKLLSVP VTYTSLKNKD IDVFLGNWMP TMEGDIAPYR DDKSVETLRE NLTGAKYTLA 
121:	TNAKGAELGI KDFKDIAAHS SELGGKIYGI EPGNDGNRLI LDMVAKDSFG LKSFEVVESS 
181:	EQGMLSQVAR AEKSGEPIVF LGWEPHPMNA NFKLTYLTGG DEVFGPNFGG ATIYTNVRKG 
241:	YVEECPNVGA FLKNLQFSLP MENEIMGKIL NDGLEGEAAA TAWLKANPAA IEPWFANVKT 
301:	KDGSADALPA VKKALGL