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3.A.1.12.13
High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7)

Accession Number:Q7CXG1
Protein Name:ABC transporter, membrane spanning protein (Proline/glycine betaine)
Length:343
Molecular Weight:37283.00
Species:Agrobacterium tumefaciens (strain C58 / ATCC 33970) [176299]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Choline

Cross database links:

eggNOG: COG4176
HEGENOM: HBG592565
Entrez Gene ID: 1134318   
Pfam: PF00528   
KEGG: atu:Atu2280   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity

References (2)

[1] “Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.”  Goodner B.et.al.   11743194
[2] “The genome of the natural genetic engineer Agrobacterium tumefaciens C58.”  Wood D.W.et.al.   11743193

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDLHRARQRR CRPSLLYWSN SGDNRSLKKL RFFVVCAIPD AKPLCIFAGI ALIHERSFLT 
61:	VEWLSAPENR LPIGRYAKEA IDWLTGNLAF FFDWLSFIFQ SVINALLYVL QAPHPLIIVA 
121:	IVTALSAWTR RSAGMPIFTA LGLLLIINLG YWKATTETLA LVIAASAVCM IIGIPLGILA 
181:	ARRKWIYAGM RPALDLMQTI PTFVYLIPAL VLFGLGMVPG LIATVIFAIP APVRLTRLGI 
241:	VSTPPALVEA AVAFGATPSQ VLRKVELPFA APQIMAGLTQ TIMLSLSMVV ISALVGANGL 
301:	GVPVVRALNT VNIAMGFEAG LCIVILAIVL DRLFRLPGTE DDL