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3.A.1.135.8
Multidrug efflux pump, EfrCD.  Exports daunorubicin, doxorubicin, ethidium and Hoechst 33342.  Mediates efflux of fluorescent substrates and confers resistance towards multiple dyes and drugs including fluoroquinolones (Hürlimann et al. 2016).

Accession Number:Q837P4
Protein Name:ABC transporter, ATP-binding/permease protein
Length:589
Molecular Weight:66152.00
Species:Enterococcus faecalis (strain ATCC 700802 / V583) [226185]
Number of TMSs:5
Substrate daunorubicin, doxorubicin, ethidium, Hoechst 33342, Fluoroquinolones

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTDLIKASKF FYHYLKRYKV SFLFIFLAIF AATYLQVKAP QFVGEAIQEL AKYAVNVMQG 
61:	KDDKSAFVSV IWKLLIFYVL TSAASFIYSI LFTQVVGKST NRMRIGLFNK LEKLTIRFFD 
121:	SHQDGEILSR FTSDLDNIQN SLNQALLQVL TNIALLVGVL IMMFRQNVEL AWATIASTPI 
181:	AILIAVFVIS KARKYVDLQQ DEVGKLNGYM DEKISGQRVI ITNGLQEETI DGFLEQNEKV 
241:	RAATYKGQVY SGLLFPMMQG MSLVNTAIVI FFGGWLAING SVDRAAALGL VVMFVQYSQQ 
301:	YYQPLMQISS GYSMIQLAVT GARRLNEMFD EPDEIRPENG EKLEEINKAV ALNHVVFGYN 
361:	PETPVLKDVS IHVDKGEMVA LVGPTGSGKT TIMNLMNRFY DVNEGAVTFD GVDIREMDLD 
421:	SLRSHVGIVL QESVLFSGTI RENIAFGKPE ATDEEIVQAA KQANIHEFIV NLEQGYDTEI 
481:	TEENNLFSTG QKQLVSIART IITNPELLIL DEATSNVDTV TEAKIQKAMD EAIKGRTSFV 
541:	IAHRLKTILN ADRIIVLRDG EVIEEGNHHE LVEQDGFYAE LYKNQFVFE