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3.A.1.135.8
Multidrug efflux pump, EfrCD.  Exports daunorubicin, doxorubicin, ethidium and Hoechst 33342.  Mediates efflux of fluorescent substrates and confers resistance towards multiple dyes and drugs including fluoroquinolones (Hürlimann et al. 2016).

Accession Number:Q837P5
Protein Name:ABC transporter, ATP-binding/permease protein
Length:571
Molecular Weight:62840.00
Species:Enterococcus faecalis (strain ATCC 700802 / V583) [226185]
Number of TMSs:6
Substrate daunorubicin, doxorubicin, ethidium, Hoechst 33342, Fluoroquinolones

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDLIIQHAKK YKGSVVIALL AVIVMVVSAL WQPKLLQQVL EAIMNDDSDK MKNLGIQLIA 
61:	IAGLGLVAGV INTIFSAKVA QGVSADIREA TFRKIQTFSF GNIEKFSAGN LVVRLTNDVT 
121:	QIQNVIMIAL QTLFRIPFLF IGSFILAMLT LPQLWWVIVA LVIAVILISM LSFSQMGKHF 
181:	MIIQNLIDKI NGIAKENLLG IRVVKSFVQE KNQLSRFTKV SEELTTHNLI VGSLFAVMIP 
241:	AFMLVANLAV VGSIFFVSNL VKDDPTLIGG VASFMNYLMQ IMMAIIIGGM MMMMTSRAAV 
301:	SIKRIKEVME TEPDVTYKKV PEQELIGSVE FDHVSFRYPG DEEDTLKDIS FSIQPGEMIG 
361:	IVGATGAGKS TLAQLIPRLF DPTEGKIEVG GVDLREVNEH SLRKTVSFVL QKAILFSGTI 
421:	AQNLRHGKRD ASEADMERAS GIAQAKEFIE KLAEGYDAPV EERSNNFSGG QKQRLSITRG 
481:	VIGEPKILIL DDSTSALDAR SERLVREALD KELKETTTIV IAQKISSVVH ADRILVLDNG 
541:	RLVGEGTHEE LAATNPVYQE IYETQKGKEE A