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2.A.82.1.2
The organic solute transporter OSTα/OSTβ or SLC51A/SLC51B (transports the same anions as the 2.A.82.1.1 system) (The ileal enterocyte basolateral bile acid transporter; uses facilitated diffusion vian an anion:anion antiport mechanism with sulfate or bicarbonate as the counter anion) (Dawson et al., 2005).  Transports steroid-derived molecules as well as glycine and taurine conjugated bile acids (Ballatori et al. 2013).  Heterodimerization increases stability, facilitates post-translational modification and is required for delivery to the plasma membrane.  This system is essential for intestinal bile acid and dietary lipid absorption (Ballatori et al. 2013).

Accession Number:Q86UW1
Protein Name:OST alpha
Length:340
Molecular Weight:37735.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Steroid derivatives, Sulfate, bicarbonate

Cross database links:

Genevestigator: Q86UW1
eggNOG: prNOG16804
HEGENOM: HBG715873
RefSeq: NP_689885.4   
Entrez Gene ID: 200931   
Pfam: PF03619   
OMIM: 612084  gene
KEGG: hsa:200931   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (5)

[1] “Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta.”  Seward D.J.et.al.   12719432
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.”  Ballatori N.et.al.   16317684
[4] “The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.”  Landrier J.-F.et.al.   16269519
[5] “FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.”  Lee H.et.al.   16251721

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEPGRTQIKL DPRYTADLLE VLKTNYGIPS ACFSQPPTAA QLLRALGPVE LALTSILTLL 
61:	ALGSIAIFLE DAVYLYKNTL CPIKRRTLLW KSSAPTVVSV LCCFGLWIPR SLVLVEMTIT 
121:	SFYAVCFYLL MLVMVEGFGG KEAVLRTLRD TPMMVHTGPC CCCCPCCPRL LLTRKKLQLL 
181:	MLGPFQYAFL KITLTLVGLF LVPDGIYDPA DISEGSTALW INTFLGVSTL LALWTLGIIS 
241:	RQARLHLGEQ NMGAKFALFQ VLLILTALQP SIFSVLANGG QIACSPPYSS KTRSQVMNCH 
301:	LLILETFLMT VLTRMYYRRK DHKVGYETFS SPDLDLNLKA