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2.A.6.2.26
The multidrug efflux pump, VmeAB-VpoC (Matsuo et al., 2007).  There are 11 RND-type efflux transporters in Vibrio parahaemolyticus, and several (VmeCD, VmeEF and VmeYZ) contribute not only to intrinsic drug resistance but also to virulence (Matsuo et al. 2013).

Accession Number:Q87SJ8
Protein Name:VpoC
Length:442
Molecular Weight:47983.00
Species:Vibrio parahaemolyticus [670]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate drugs

Cross database links:

HEGENOM: HBG647495
RefSeq: NP_796804.1   
Entrez Gene ID: 1187893   
Pfam: PF02321   
BioCyc: VPAR223926:VP0425-MONOMER   
KEGG: vpa:VP0425   

Gene Ontology

GO:0019867 C:outer membrane
GO:0005215 F:transporter activity
GO:0015031 P:protein transport

References (1)

[1] “Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae.”  Makino K.et.al.   12620739

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKLLPLFIS AALGGISSSA WADSLAEIYD LAKQNDPQLL SVAAQRDRAF EAITSSRSAL 
61:	LPQINLTAGY NLTRGDTEYD SNLISDVSND SNALTAGVNF SQELYNRASW ITLDTAEKSA 
121:	RQADATYAAA QQGLILRVSQ AYFEVLRAQD NLVFVRAEKA AVGRQLEQTK QRFEVGLSAI 
181:	TDVHDAQAQY DAVLADEVLA ENDLINSYES LREITGQEHK NLNVLDTNRF SATRTNSPAE 
241:	TLIDEAKTKN LSLLSARISQ DIARDNISLA SSGHLPTLSL DGGYNYGDTS NSARDNTTDN 
301:	FNIGVNLAVP LYTGGNVTSQ TKQAEFAYVA ASEDLEAQYR SVVKDVRAQN NNINASIGAL 
361:	KAYEQSVVSA RSALEATEAG FDVGTRTIVD VLDATRRLYD ANKNLSDARY NYILSVLQLR 
421:	QAVGTLSEQD ILDVDAGLKP AK