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1.A.1.19.3
Alkalinization-activated Ca2+-selective channel, Cation channel of sperm 1, CatSper1, required for male fertility and the hyperactivated motility of spermatozoa. These channels require auxiliary subunits, CatSper β, γ and δ for activity (Chung et al., 2011; Liu et al., 2007).

Accession Number:Q8BVN3
Protein Name:Cation channel sperm-associated protein 4 aka CatSper4
Length:442
Molecular Weight:51130.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell projection1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q8BVN3
eggNOG: roNOG17803
HEGENOM: HBG126349
RefSeq: NP_001123502.1    NP_808534.1   
Entrez Gene ID: 329954   
Pfam: PF00520   
KEGG: mmu:329954   

Gene Ontology

GO:0001669 C:acrosomal vesicle
GO:0005929 C:cilium
GO:0020017 C:flagellar membrane
GO:0016021 C:integral to membrane
GO:0005227 F:calcium activated cation channel activity
GO:0005262 F:calcium channel activity
GO:0005515 F:protein binding
GO:0005244 F:voltage-gated ion channel activity
GO:0006816 P:calcium ion transport
GO:0030154 P:cell differentiation
GO:0001539 P:ciliary or flagellar motility
GO:0007275 P:multicellular organismal development
GO:0006814 P:sodium ion transport
GO:0030317 P:sperm motility
GO:0007283 P:spermatogenesis
GO:0055085 P:transmembrane transport

References (7)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.”  Jin J.-L.et.al.   16107607
[5] “Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility.”  Li H.-G.et.al.   17347248
[6] “Catsper3 and catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.”  Jin J.-L.et.al.   17344468
[7] “All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.”  Qi H.et.al.   17227845

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSEKHKWWQQ VENIDITHLG PKRKAYELLG RHEEQVLINR RDVMEKKDAW DVQEFITQMY 
61:	IKQLLRHPAF QLLLAFLLLS NAITIALRTN SYLGQKHYEL FSTIDDIVLT ILICEVLLGW 
121:	LNGFWIFWKD GWNILNFAIV FILFMGFFIK QLDMVAITYP LRVLRLVHVC MAVEPLARII 
181:	KVILQSMPDL ANVMALILFF MLVFSVFGVT LFGAFVPKHF QNMGVALYTL FICITQDGWL 
241:	DIYTDFQMDE REYAMEVGGA IYFAVFITLG AFIGLNLFVV VVTTNLEQMM KTGEEEGHLN 
301:	IKFTETEEDE DWTDELPLVH CTEARKDTST VPKEPLVGGP LSNLTEKTCD NFCLVLEAIQ 
361:	ENLMEYKEIR EELNMIVEEV SSIRFNQEQQ NVILHKYTSK SATFLSEPPE GANKQDLITA 
421:	LVSREKVSDS NINMVNKHKF SH