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3.A.11.1.2
The single stranded DNA uptake competence transporter, ComEA/ComEC/ComFA (Cvitkovitch 2001; Claverys et al. 2006Claverys et al. 2006).

Accession Number:Q8CWM9
Protein Name:ComFA
Length:432
Molecular Weight:49563.00
Species:Streptococcus pneumoniae (strain ATCC BAA-255 / R6) [171101]
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ssDNA

Cross database links:

eggNOG: COG4098
HEGENOM: HBG535566
RefSeq: NP_359604.1   
Entrez Gene ID: 933722   
Pfam: PF00270    PF00271   
BioCyc: SPNE171101:SPR2013-MONOMER   
KEGG: spr:spr2013   

Gene Ontology

GO:0005524 F:ATP binding
GO:0008026 F:ATP-dependent helicase activity
GO:0003676 F:nucleic acid binding

References (1)

[1] “Genome of the bacterium Streptococcus pneumoniae strain R6.”  Hoskins J.et.al.   11544234

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKVNLDYLGR LFTENELTEE ERQLAEKLPA MRKEKGKLFC QRCNSTILEE WYLPIGAYYC 
61:	RECLLMKRVR SDQTLYYFPQ EDFPKQDVLK WRGQLTPFQE KVSEGLLQAV DKQKPTLVHA 
121:	VTGAGKTEMI YQVVAKVINA GGAVCLASPR IDVCLELYKR LQQDFSCGIA LLHGESEPYF 
181:	RTPLVVATTH QLLKFYQAFD LLIVDEVDAF PYVDNPMLYH AVKNSVKENG LRIFLTATST 
241:	NELDKKVRLG ELKRLNLPRR FHGNPLIIPK PIWLSDFNRY LDKNRLSPKL KSYIEKQRKT 
301:	AYPLLIFASE IKKGEQLAEI LQEQFPNEKI GFVSSVTEDR LEQVQAFRDG ELTILISTTI 
361:	LERGVTFPCV DVFVVEANHR LFTKSSLIQI GGRVGRSMDR PTGDLLFFHD GLNASIKKAI 
421:	KEIQMMNKEA GL