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3.A.11.1.2
The single stranded DNA uptake competence transporter, ComEA/ComEC/ComFA (Cvitkovitch 2001; Claverys et al. 2006Claverys et al. 2006).

Accession Number:Q8DQ40
Protein Name:ComFA
Length:746
Molecular Weight:84619.00
Species:Streptococcus pneumoniae (strain ATCC BAA-255 / R6) [171101]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ssDNA

Cross database links:

eggNOG: COG0658
HEGENOM: HBG694670
RefSeq: NP_358451.1   
Entrez Gene ID: 934397   
Pfam: PF03772   
BioCyc: SPNE171101:SPR0857-MONOMER   
KEGG: spr:spr0857   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0016787 F:hydrolase activity
GO:0030420 P:establishment of competence for transformation

References (1)

[1] “Genome of the bacterium Streptococcus pneumoniae strain R6.”  Hoskins J.et.al.   11544234

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MLQWIKNFSI PLIYLSFLLL WLYYAIFSAS YLALLGFVFL LVCLFIQFPW KSAGKVLIIC 
61:	GIFGFWFVFQ NWQQSQASQN LADSVERVRI LPDTVKVNGD SLSFRGKADG RIFQVYYKLQ 
121:	SEEEKEAFQA LTDLHEIGLE GKLSEPEGQR NFGGFNYQAY LKTQGIYQTL NIKKIQSLQK 
181:	IGSWDIGENL SSLRRKAVVW IKTHFPDPMR NYMTGLLLGH LDTDFEEMNE LYSSLGIIHL 
241:	FALSGMQVGF FMNGFKKLLL RLGLTQEKLK WLTYPFSLIY AGLTGFSASV IRSLLQKLLA 
301:	QHGVKGLDNF ALTVLVLFIV MPNFFFTAGG VLSCAYAFIL TMTSKEGEGL KAVASESLVI 
361:	SLGILPILSF YFAEFQPWSI LLTFVFSFLF DLTFLPLLSI LFVLSFLYPV IQLNFIFEWL 
421:	EGIIRLVSQV TSRPLVFGQP NTWLLILLLI SLALVYDLRK NIKKLTVLCL LITGLFLLTK 
481:	HPLENEITML DVGQGESIFL RDVTGKTILI DVGGKAESYK KIKKWQEKMT TSNAQRSLIP 
541:	YLKSRGVAKI DQLILTNTDK EHVGDLSEMT KAFHVGEILV SKDSLKQKEF VAELQATQTK 
601:	VRSMIVGENL PIFGSQLEVL SPRKMGDGGH DDTLVLYGKF LDKQFLFTGN LEEKGEKDLL 
661:	KHYPDLKVNV LKASQHGNKK SSSPAFLEKL KPELTLISVG KSNRMKLPYQ ETLTRLEGIN 
721:	SKVYRTDQQG AIRFKGLDSW KIESVR