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5.B.5.1.1
The multihaem c-type cytochrome quinol:Fe3+ /Mn3 /4+ oxidoreductase, Cym/Mtr (Shi et al., 2007).  MtrABC is composed of two decahaem cytochromes (MtrA & B) brought together inside a transmembrane β-porin (MtrC) to transport electrons across the outer membrane to mineral based electron acceptors (White et al. 2012).  Conduction through MtrCAB directly to Fe(III) oxides occurs both in vitro in liposomes and in vivo, allowing anaerobic, solid-phase iron respiration (White et al. 2013). MtrC interacts with the surface of MtrAB, extending ∼70 Å from the membrane surface and allowing the terminal hemes to interact with both MtrAB and an extracellular acceptor. MtrA fully extends through the length of MtrB, with ∼30 Å being exposed into the periplasm. MtrCAB can reduce Fe(III) citrate with STC as an electron donor, disclosing a direct interaction between MtrCAB and STC (Edwards et al. 2018). MtrC, but not UndA (a paralog of MtrC of 843 aas; F8UWD6), appears to be the primary reductase of flavins to ensure fast indirect extracellular electron transfer (EET), which plays a crucial role in microbial fuel cell (MFC) electricity generation in Shewanella putrefaciens CN32 (Wu et al. 2018). The dimensions of MtrAB are approximately 105 x 60 x 35 Å and approximately 170 x 60 x 45 Å for MtrCAB. Their shapes suggest that MtrC interacts with the surface of MtrAB, extending approximately 70 Å from the membrane surface and allowing the terminal hemes to interact with both MtrAB and an extracellular acceptor. MtrA fully extends through the length of MtrB, with approximately 30 Å being exposed into the periplasm (Edwards et al. 2018).

Accession Number:Q8E8S0
Protein Name:CymA
Length:187
Molecular Weight:20822.00
Species:Shewanella oneidensis [70863]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

HEGENOM: HBG297153
RefSeq: NP_720107.1   
Entrez Gene ID: 1172176   
Pfam: PF03264   
BioCyc: SONE211586:SO_4591-MONOMER   
KEGG: son:SO_4591   

Gene Ontology

GO:0008940 F:nitrate reductase activity
GO:0000104 F:succinate dehydrogenase activity

References (1)

[1] “Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis.”  Heidelberg J.F.et.al.   12368813

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNWRALFKPS AKYSILALLV VGIVIGVVGY FATQQTLHAT STDAFCMSCH SNHSLKNEVL 
61:	ASAHGGGKAG VTVQCQDCHL PHGPVDYLIK KIIVSKDLYG FLTIDGFNTQ AWLDENRKEQ 
121:	ADKALAYFRG NDSANCQHCH TRIYENQPET MKPMAVRMHT NNFKKDPETR KTCVDCHKGV 
181:	AHPYPKG