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5.B.5.1.1
The multihaem c-type cytochrome quinol:Fe3+ /Mn3 /4+ oxidoreductase, Cym/Mtr (Shi et al., 2007).  MtrABC is composed of two decahaem cytochromes (MtrA & B) brought together inside a transmembrane β-porin (MtrC) to transport electrons across the outer membrane to mineral based electron acceptors (White et al. 2012).  Conduction through MtrCAB directly to Fe(III) oxides occurs both in vitro in liposomes and in vivo, allowing anaerobic, solid-phase iron respiration (White et al. 2013). MtrC interacts with the surface of MtrAB, extending ∼70 Å from the membrane surface and allowing the terminal hemes to interact with both MtrAB and an extracellular acceptor. MtrA fully extends through the length of MtrB, with ∼30 Å being exposed into the periplasm. MtrCAB can reduce Fe(III) citrate with STC as an electron donor, disclosing a direct interaction between MtrCAB and STC (Edwards et al. 2018). MtrC, but not UndA (a paralog of MtrC of 843 aas; F8UWD6), appears to be the primary reductase of flavins to ensure fast indirect extracellular electron transfer (EET), which plays a crucial role in microbial fuel cell (MFC) electricity generation in Shewanella putrefaciens CN32 (Wu et al. 2018). The dimensions of MtrAB are approximately 105 x 60 x 35 Å and approximately 170 x 60 x 45 Å for MtrCAB. Their shapes suggest that MtrC interacts with the surface of MtrAB, extending approximately 70 Å from the membrane surface and allowing the terminal hemes to interact with both MtrAB and an extracellular acceptor. MtrA fully extends through the length of MtrB, with approximately 30 Å being exposed into the periplasm (Edwards et al. 2018).

Accession Number:Q8EG33
Protein Name:MtrC
Length:735
Molecular Weight:78616.00
Species:Shewanella oneidensis [70863]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Electrons

Cross database links:

HEGENOM: HBG678302
RefSeq: NP_717388.1   
Entrez Gene ID: 1169553   
BioCyc: SONE211586:SO_1779-MONOMER   
KEGG: son:SO_1779   

References (1)

[1] “Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis.”  Heidelberg J.F.et.al.   12368813
Structure:
4LMH     

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMKRFNFNTA TKAMLGAGLL SLLLTGCGGS DGKDGEDGKP GVVGVNINST STLKAKFTNA 
61:	TVDAGKVTVN FTLENANGVA VLGLTKDHDL RFGIAQLTPV KEKVGETEAD RGYQWQAYIN 
121:	AKKEPGTVPS GVDNLNPSTQ FQANVESANK CDTCLVDHGD GSYSYTYQVN VANVTEPVKV 
181:	TYSADATQRA TMELELPQLA ANAHFDWQPS TGKTEGIQTR NVVSIQACYT CHQPESLALH 
241:	GGRRIDIENC ASCHTATSGD PESGNSIEFT YMIHAIHKGG ERHTFDATGA QVPAPYKIIG 
301:	YGGKVIDYGK VHYPQKPAAD CAACHVEGAG APANADLFKA DLSNQACIGC HTEKPSAHHS 
361:	STDCMACHNA TKPYGGTGSA AKRHGDVMKA YNDSLGYKAK FSNIGIKNNA LTFDVQILDN 
421:	KDQPIGKEFI SDPSAYTKSS IYFSWGIDKD YPAYTAGSRY SDRGFALSNS KVSTYNEATK 
481:	TFTIDSTNSN LKLPADLTGM NVELYAGVAT CFNKGGYGVE DVVATPCSTD TRYAYIQDQP 
541:	FRFKWNGTDT NSAAEKRRAI IDTAKCSGCH NKEIVHYDNG VNCQACHTPD KGLKTDNTYP 
601:	GTKVPTSFAW KAHESEGHYL KYAGVQSGTV LKTDCATCHT ADKSNVVTGI ALGRSPERAW 
661:	LYGDIKNNGA VIWVSSDAGA CLSCHQKYLS DAAKSHIETN GGILNGTSAA DVQTRASESC 
721:	ATCHTPSQLM EAHGN