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5.A.2.1.2
The DsbI (223 aas and 4 TMSs in a 3 + 1 arrangement)/DsbL (222 aas and 1 N-terminal TMS) disulfide bond oxidoreductase/thio:disulfide interchange protein together form a dithiol oxidase system, acting on the periplasmic enzyme arylsulfate sulfotransferase, AssT (598 aas, 1 N-terminal TMS, Q8FDI4) which requires a disulfide bond for activity. The 3-d structure of DsbL at 1.55 Å resolution has been determined. DsbL is one of the most reactive oxidizing thioredoxin-like protein known (Grimshaw et al. 2008).  These three enzymes are encoded within a tricistronic operon.

Accession Number:Q8FDI3
Protein Name:Protein-disulfide oxidoreductase DsbI
Length:223
Molecular Weight:25117.00
Species:Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [199310]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Electrons

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGIKGMWKDL RTSPVDTLVR WQEQRLLWLL MAVAMGALII LAHSFFQIYL YMAPCEQCVY 
61:	IRYAMFVMVI GGLVAAINPK NIILKLIGCV MAFYGSILGL KFSLKLNDIH HAVHNPDPDS 
121:	LFGVQGCSTD PTFPFNLPLA QWAPNWFKPT GDCGYDAPIV PDGVTLSSTQ QWFVEMYQQS 
181:	EGWYLLPPWH FMNMAQACML AFGMCLVLLV IMSGAWALKI IRG