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9.A.39.1.2
Iron regulated surface determinant, Haptoglobin receptor A (HarA or IsdH) precursor (891 aas). Also binds hemoglobin and haptoglobin/hemoglobin complexes with nM or µM binding constants to an 8-stranded anti-parallel β-barrel domain (Dryla et al., 2007). The functionally distinct NEAT (NEAr Transporter) domain within IsdH extracts heme from methemoglobin (Pilpa et al., 2009). Hemoglobin/myoglobin receptor B (IsdB), transferrin, hemin, fetuin, asialofetuin receptor (IsdA), and the cell wall conduit, IsdC may comprise the full system (Villareal et al., 2008).

Accession Number:Q8KQR1
Protein Name:IsdC
Length:227
Molecular Weight:24855.00
Species:Staphylococcus aureus (strain NCTC 8325) [93061]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1 / Peptidoglycan-anchor2
Substrate iron-heme complex

Cross database links:

eggNOG: COG5386 COG5386
HEGENOM: HBG692914 HBG692914
RefSeq: YP_499628.1   
Entrez Gene ID: 3919244   
Pfam: PF05031   
KEGG: sao:SAOUHSC_010    sao:SAOUHSC_010   

Gene Ontology

GO:0005618 C:cell wall
GO:0005576 C:extracellular region
GO:0046872 F:metal ion binding

References (12)

[1] “Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein.”  Taylor J.M.et.al.   11952908
[2] “An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.”  Mazmanian S.K.et.al.   11830639
[3] “In vivo heme scavenging by Staphylococcus aureus IsdC and IsdE proteins.”  Mack J.et.al.   15240116
[4] “Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC.”  Marraffini L.A.et.al.   15718231
[5] “Heme binding in the NEAT domains of IsdA and IsdC of Staphylococcus aureus.”  Pluym M.et.al.   18194816
[6] “Crystal structure of the heme-isdC complex, the central conduit of the Isd iron/heme uptake system in Staphylococcus aureus.”  Sharp K.H.et.al.   17287214
[7] “Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein.”  Taylor J.M.et.al.   11952908
[8] “An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.”  Mazmanian S.K.et.al.   11830639
[9] “In vivo heme scavenging by Staphylococcus aureus IsdC and IsdE proteins.”  Mack J.et.al.   15240116
[10] “Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC.”  Marraffini L.A.et.al.   15718231
[11] “Heme binding in the NEAT domains of IsdA and IsdC of Staphylococcus aureus.”  Pluym M.et.al.   18194816
[12] “Crystal structure of the heme-isdC complex, the central conduit of the Isd iron/heme uptake system in Staphylococcus aureus.”  Sharp K.H.et.al.   17287214
Structure:
2O6P     

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNILKVFNT TILALIIIIA TFSNSANAAD SGTLNYEVYK YNTNDTSIAN DYFNKPAKYI 
61:	KKNGKLYVQI TVNHSHWITG MSIEGHKENI ISKNTAKDER TSEFEVSKLN GKIDGKIDVY 
121:	IDEKVNGKPF KYDHHYNITY KFNGPTDVAG ANAPGKDDKN SASGSDKGSD GTTTGQSESN 
181:	SSNKDKVENP QTNAGTPAYI YAIPVASLAL LIAITLFVRK KSKGNVE