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3.A.1.12.9
The salt-induced glycine betaine OtaABC transporter (Schmidt et al., 2007)

Accession Number:Q8U4S5
Protein Name:OtaA
Length:450
Molecular Weight:49574.00
Species:Methanosarcina mazei [2209]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate Glycine betaine

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_632064.1   
Entrez Gene ID: 1478382   
Pfam: PF00005    PF00571   
BioCyc: MMAZ192952:MM0040-MONOMER   
KEGG: mma:MM_0040   

Gene Ontology

GO:0016020 C:membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0006865 P:amino acid transport

References (2)

[1] “Identification of a salt-induced primary transporter for glycine betaine in the methanogen Methanosarcina mazei Go1.”  Roessler M.et.al.   11976081
[2] “The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.”  Deppenmeier U.et.al.   12125824

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSEIAKIEIK NLTKIFGKNP QEVLSLLKGG HTKNEIFEKT KQTVGLNNIN FDVYDGEIFV 
61:	LMGLSGSGKS TLLRCINRLI NPTSGKILID GQDISVMDAE QLRKVRRTKL GMVFQNFALL 
121:	PHRTVLDNVA YGLEIQGVPK NERYSKAVEA INTVGLKGYE DSKITQLSGG MKQRVGLARA 
181:	LANDPDILLM DEAFSALDPL IRNEMQDELL SLEDKLQKTI VFVSHDLDEA LKLGDRIALM 
241:	KDGEIVQIGT PEEILTNPAD NYVSQFVKGV DRSKVLTAEN VMWRPEPLVS INSGPRVAVQ 
301:	LMKEYGISSI FVVEGKNRLL KGIIMIDDAV EALKSKKNLE SIIREIPSIP LDMPLSEIIP 
361:	LIANSSYPLP VVDESRKLKG IIIRGTVLGA LAMSEDVPEE ASAGEGEPVQ DKNKEILDNK 
421:	GQQESPASEK GLSSEVEDIS QKSENVEVKM