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8.A.30.1.1
Nedd4-2 (1004 aas, 0 TMSs: Ubiquitin protein ligase, E3)/Nedd4 interacting protein-2 (311 aas; 3 TMSs: ww domain binding protein 5 (N4WBP5A)) (Zhou, et al., 2007)

Accession Number:Q91ZP6
Protein Name:NEDD4 family-interacting protein 2 aka Ndfip2
Length:311
Molecular Weight:33638.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q91ZP6
RefSeq: NP_083837.1   
Entrez Gene ID: 76273   
Pfam: PF10176   
KEGG: mmu:76273   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0032585 C:multivesicular body membrane

References (4)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.”  Konstas A.-A.et.al.   12050153
[4] “N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.”  Shearwin-Whyatt L.M.et.al.   15252135

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	RRSASDAELS AGAEGATGSE AAPPGDLGGR TRGGGRGSAA AAATTSTREA EGAERRGDTP 
61:	ARKPDPEAGR MDHHQLGTGR YQVLHNEEDN SESSAVEQPS TSSLAAPTVE AAASAPALDP 
121:	DSPPPYSSIT VEAPTTSDTD VYSEFYPVPP PYSVATSLPT YDEAEKAKAA ALAAAAADAP 
181:	QRNQEEDCTP RDDFSDVEQL RVGNDGIFML AFFMAFIFNW LGFCLSFCIT NTIAGRYGAI 
241:	CGFGLSLIKW ILIVRFSDYF TGYFNGQYWL WWIFLVLGLL LFFRGFVNYL KVRNMSESMA 
301:	AAHRTRYFFL L