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1.A.1.19.3
Alkalinization-activated Ca2+-selective channel, Cation channel of sperm 1, CatSper1, required for male fertility and the hyperactivated motility of spermatozoa. These channels require auxiliary subunits, CatSper β, γ and δ for activity (Chung et al., 2011; Liu et al., 2007).

Accession Number:Q91ZR5
Protein Name:Cation channel sperm-associated protein 1 aka CatSper1
Length:686
Molecular Weight:78706.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell projection1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q91ZR5
eggNOG: maNOG19130
HEGENOM: HBG125814
RefSeq: NP_647462.1   
Entrez Gene ID: 225865   
Pfam: PF00520   
KEGG: mmu:225865   

Gene Ontology

GO:0005929 C:cilium
GO:0020017 C:flagellar membrane
GO:0016021 C:integral to membrane
GO:0005515 F:protein binding
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport
GO:0030154 P:cell differentiation
GO:0001539 P:ciliary or flagellar motility
GO:0007342 P:fusion of sperm to egg plasma membrane
GO:0007275 P:multicellular organismal development
GO:0051925 P:regulation of calcium ion transport via vol...
GO:0030317 P:sperm motility
GO:0007283 P:spermatogenesis
GO:0055085 P:transmembrane transport

References (11)

[1] “A sperm ion channel required for sperm motility and male fertility.”  Ren D.et.al.   11595941
[2] “Positive selection for indel substitutions in the rodent sperm protein catsper1.”  Podlaha O.et.al.   15930155
[3] “CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.”  Carlson A.E.et.al.   14657352
[4] “CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility.”  Nikpoor P.et.al.   14688170
[5] “Identical phenotypes of CatSper1 and CatSper2 null sperm.”  Carlson A.E.et.al.   16036917
[6] “Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel.”  Kirichok Y.et.al.   16467839
[7] “Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm.”  Marquez B.et.al.   17174296
[8] “CatSperbeta, a novel transmembrane protein in the CatSper channel complex.”  Liu J.et.al.   17478420
[9] “Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility.”  Li H.-G.et.al.   17347248
[10] “All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility.”  Qi H.et.al.   17227845
[11] “A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein.”  Wang H.et.al.   19516020

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDQSSRRDES YHETHPGSLD PSHQSHPHPH PHPTLHRPNQ GGVYYDSPQH GMFQQPYQQH 
61:	GGFHQQNELQ HLREFSDSHD NAFSHHSYQQ DRAGVSTLPN NISHAYGGSH PLAESQHSGG 
121:	PQSGPRIDPN HHPHQDDPHR PSEPLSHPSS TGSHQGTTHQ QYHERSHHLN PQQNRDHADT 
181:	ISYRSSTRFY RSHAPFSRQE RPHLHADHHH EGHHAHSHHG EHPHHKEQRH YHGDHMHHHI 
241:	HHRSPSASQL SHKSHSTLAT SPSHVGSKST ASGARYTFGA RSQIFGKAQS RESLRESASL 
301:	SEGEDHVQKR KKAQRAHKKA HTGNIFQLLW EKISHLLLGL QQMILSLTQS LGFETFIFIV 
361:	VCLNTVILVA QTFTELEIRG EWYFMVLDSI FLSIYVLEAV LKLIALGLEY FYDPWNNLDF 
421:	FIMVMAVLDF VLLQINSLSY SFYNHSLFRI LKVFKSMRAL RAIRVLRRLS ILTSLHEVAG 
481:	TLSGSLPSIT AILTLMFTCL FLFSVVLRAL FQDSDPKRFQ NIFTTLFTLF TMLTLDDWSL 
541:	IYIDNRAQGA WYIIPILMIY IVIQYFIFLN LVIAVLVDNF QMALLKGLEK VKLEQAARVH 
601:	EKLLDDSLTD LNKADANAQM TEEALKMQLI EGMFGNMTVK QRVLHFQFLQ LVAAVEQHQQ 
661:	KFRSQAYVID ELVDMAFEAG DDDYGK