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9.A.39.1.2
Iron regulated surface determinant, Haptoglobin receptor A (HarA or IsdH) precursor (891 aas). Also binds hemoglobin and haptoglobin/hemoglobin complexes with nM or µM binding constants to an 8-stranded anti-parallel β-barrel domain (Dryla et al., 2007). The functionally distinct NEAT (NEAr Transporter) domain within IsdH extracts heme from methemoglobin (Pilpa et al., 2009). Hemoglobin/myoglobin receptor B (IsdB), transferrin, hemin, fetuin, asialofetuin receptor (IsdA), and the cell wall conduit, IsdC may comprise the full system (Villareal et al., 2008).

Accession Number:Q931P4
Protein Name:Iron-regulated surface determinant protein H aka IsdH aka HarA
Length:891
Molecular Weight:100466.00
Species:Staphylococcus aureus (strain Mu50 / ATCC 700699) [158878]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1 / Peptidoglycan-anchor2
Substrate iron-heme complex

Cross database links:

HEGENOM: HBG215988
RefSeq: NP_372255.1   
Entrez Gene ID: 1121706   
Pfam: PF05031    PF04650   
BioCyc: SAUR158878:SAV1731-MONOMER   
KEGG: sav:SAV1731   

Gene Ontology

GO:0005618 C:cell wall
GO:0005576 C:extracellular region
GO:0016020 C:membrane

References (1)

[1] “Whole genome sequencing of meticillin-resistant Staphylococcus aureus.”  Kuroda M.et.al.   11418146
Structure:
2E7D   2Z6F   3QUG   3QUH   3VTM   3VUA     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKHHPKLRS FYSIRKSTLG VASVIVSTLF LITSQHQAQA AENTNTSDKI SENQNNNATT 
61:	TQQPKDTNQT QPATQPVITA KNYPAADESL KDAIKDPALE NKEHDIGPRE QVNFQLLDKN 
121:	NETQYYHFFS IKDPADVYYT KKKAEVELDI NTASTWKKFE VYENNQKLPV RLVSYSPVPE 
181:	DHAYIRFPVS DGTQELKIVS STQIDDGEET NYDYTKLVFA KPIYNDPSLV KSDTNDAVVT 
241:	NDQSSSDASN QTNTNTSNQN TSTTNNANNQ PQATTNMSQP AQPKSSANAD QASSQPAHET 
301:	NSNGNTNDKT NESSNQSDVN QQYPPADESL QDAIKNPAII DKEHTADNWR PIDFQMKNDK 
361:	GERQFYHYAS TVEPATVIFT KTGPVIELGL KTASTWKKFE VYEGDKKLPV ELVSYDSDKD 
421:	YAYIRFPVSN GTRDVKIVSS IEYGENIHED YDYTLMVFAQ PITNNPDDYV DEETYNLQKL 
481:	LAPYHKAKTL ERQVYELEKL QEKLPEKYKA EYKKKLDQTR VELADQVKSA VTEFENVTPT 
541:	NDQLTDLQEA HFVVFESEEN SESVMDGFVE HPFYTATLNG QKYVVMKTKD DSYWKDLIVE 
601:	GKRVTTVSKD PKNNSRTLIF PYIPDKAVYN AIVKVVVANI GYEGQYHVRI INQDINTKDD 
661:	DTSQNNTSEP LNVQTGQEGK VADTDVAENS STATNPKDAS DKADVIEPES DVVKDADNNI 
721:	DKDVQHDVDH LSDMSDNNHF DKYDLKEMDT QIAKDTDRNV DNSVGMSSNV DTDKDSNKNK 
781:	DKVIQLAHIA DKNNHTGKAA KLDVVKQNYN NTDKVTDKKT TEHLPSDIHK TVDKTVKTKE 
841:	KAGTPSKENK LSQSKMLPKT GETTSSQSWW GLYALLGMLA LFIPKFRKES K