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3.A.1.12.8
A proline/glycine betaine uptake system. Also reported to be a bile exclusion system that exports oxgall and other bile compounds, BilEA/EB or OpuBA/BB (required for normal virulence) (R.D. Sleator et al., 2005).

Accession Number:Q93A34
Protein Name:BilEB aka OpuBB protein
Length:504
Molecular Weight:55682.00
Species:Listeria monocytogenes [1639]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Glycine betaine, Proline

Cross database links:

Pfam: PF00528    PF04069   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005488 F:binding
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes.”  Sleator R.D.et.al.   15686563

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNTLIDTFTV RKDELFTALV QHIQISFVSL FIAVLIALPL GIYLTRHKRL AEPIIQVAAI 
61:	FQTIPSLALL GLLIPLVGIG IVPAIIALVI YALLPILRNT YTGIKEVDPA LVEASRAMGM 
121:	NKWKRLYKVQ LPLAMPVIMA GIRTAMVLII GTATLAALIG AGGLGDLILL GIDRNDNSLI 
181:	LLGAIPAALL AILFDFLLRF LEKASFKSTI ITISAGILLT AAIIVVPYFA SDKKEITVAG 
241:	KLGAEPEILI NMYKLVIEDE TDLKVNVKPN MGKTSFVFNA LKSGDIDIYP EFTGTVLETF 
301:	LKENAKTHDP EEVYTQARDG LAKDFDMTYL KPMKYNNTYA LAVSPEFAKE NNLEKISDLG 
361:	PVSDQVKAGF TLEFKDRSDG YKGIQDKYGL TFSNLKTMEP KLRYNAIKSG DINLLDAYST 
421:	DSELAQYKLK VLEDDQQLFP PYQGAPLMLT KTLDKYPELK KPLNKLAGKI TDDEMRKMNY 
481:	EVNVNGKSAY TVAKDYLKDQ GIIK