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3.A.1.12.8
A proline/glycine betaine uptake system. Also reported to be a bile exclusion system that exports oxgall and other bile compounds, BilEA/EB or OpuBA/BB (required for normal virulence) (R.D. Sleator et al., 2005).

Accession Number:Q93A35
Protein Name:BilEA aka OpuBA protein
Length:328
Molecular Weight:36777.00
Species:Listeria monocytogenes [1639]
Location1 / Topology2 / Orientation3: Secreted1
Substrate Glycine betaine, Proline

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_464946.1   
Entrez Gene ID: 984736   
Pfam: PF00005    PF00571   
BioCyc: LMON169963:LMO1421-MONOMER   
KEGG: lmo:lmo1421   

Gene Ontology

GO:0016020 C:membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0006865 P:amino acid transport

References (2)

[1] “A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes.”  Sleator R.D.et.al.   15686563
[2] “Comparative genomics of Listeria species.”  Glaser P.et.al.   11679669

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIRFDNVSKK YSDDKTAAVN NVTLDIKDGE FFVFIGPSGC GKTTTLKMIN RLIPLTTGTI 
61:	YINEKRISDY DIHELRWDIG YVLQQIALFP HMTIEENIAI VPELKKWSKE KIHDRITELL 
121:	DSVGLDPESY RHRKPAELSG GEQQRVGVVR ALAADPGIIL MDEPFSALDP ISRQRLQQDI 
181:	SALQKKIKKT IVFVTHDMQE ALALGDRICV MQGGEIVQVA TPQEIMKNPE NDFVKDFLAS 
241:	GHAFNTPILE ANFTVNDLIE ADLFYSYQTS DGTLGISSTE PVENLVRRIA EEQSIPVTDE 
301:	AGNYIGTVSN KHVMQFLARH LESSGELV