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3.A.1.14.10
The heme porter, Shp/SiaABC (HtsABC). Shp is a cell surface heme binding protein that transfers the heme directly to HstA (Nygaard et al., 2006). The crystal structure of the heme binding domain of Shp has been solved (Aranda et al., 2007). HtsABC is required for the uptake of staphyloferrin A (Beasley et al. 2009). The Shp cell surface heme receptor feeds iron-heme to the transporter in preparation for uptake (Sun et al. 2010; Ouattara et al., 2010). 

Accession Number:Q99YA2
Protein Name:Putative ABC transporter aka SiaA
Length:294
Molecular Weight:33384.00
Species:Streptococcus pyogenes serotype M1 [301447]
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Heme

Cross database links:

HEGENOM: HBG306131 HBG306131
RefSeq: NP_269807.1    YP_282891.1   
Entrez Gene ID: 3571373    902024   
Pfam: PF01497   
BioCyc: SPYO160490:SPY1795-MONOMER    SPYO293653:M5005_SPY1528-MONOMER   

Gene Ontology

GO:0005381 F:iron ion transmembrane transporter activity
GO:0006827 P:high-affinity iron ion transport
GO:0005488 F:binding

References (4)

[1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.”  Ferretti J.J.et.al.   11296296
[2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.”  Sumby P.et.al.   16088826
[3] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.”  Ferretti J.J.et.al.   11296296
[4] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.”  Sumby P.et.al.   16088826

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FASTA formatted sequence
1:	MIKRCKGIGL ALMAFFLVAC VNQHPKTAKE TEQQRIVATS VAVVDICDRL NLDLVGVCDS 
61:	KLYTLPKRYD AVKRVGLPMN PDIELIASLK PTWILSPNSL QEDLEPKYQK LDTEYGFLNL 
121:	RSVEGMYQSI DDLGNLFQRQ QEAKELRQQY QDYYRAFQAK RKGKKKPKVL ILMGLPGSYL 
181:	VATNQSYVGN LLDLAGGENV YQSDEKEFLS ANPEDMLAKE PDLILRTAHA IPDKVKVMFD 
241:	KEFAENDIWK HFTAVKEGKV YDLDNTLFGM SAKLNYPEAL DTLTQLFDHV GDHP