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3.A.1.14.10
The heme porter, Shp/SiaABC (HtsABC). Shp is a cell surface heme binding protein that transfers the heme directly to HstA (Nygaard et al., 2006). The crystal structure of the heme binding domain of Shp has been solved (Aranda et al., 2007). HtsABC is required for the uptake of staphyloferrin A (Beasley et al. 2009). The Shp cell surface heme receptor feeds iron-heme to the transporter in preparation for uptake (Sun et al. 2010; Ouattara et al., 2010). 

Accession Number:Q99YA3
Protein Name:Ferrichrome transport system permease protein
Length:340
Molecular Weight:36076.00
Species:Streptococcus pyogenes serotype M1 [301447]
Number of TMSs:9
Substrate Heme

Cross database links:

HEGENOM: HBG700016 HBG700016
Entrez Gene ID: 3571372    902023   
Pfam: PF01032   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity

References (2)

[1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.”  Ferretti J.J.et.al.   11296296
[2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.”  Sumby P.et.al.   16088826

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTASDLQRDQ SLLAKKRFRS GLYLVLLILS LLFLAVIALS LGGLAVSYGA IVKGLFVAYD 
61:	PQVALIYDLR FPRIVIALLA GAGIAVSGVL FQAVLKNPIS DPAIIGICSG ASFMVLVSSL 
121:	LLPQLLLYGP IVSFLGGGVS FLLIYGLAWK KGLNPIRLIL TGIAINALFM GLSTALTSFF 
181:	TSASPMVNAL LAGHISQKTW ADVGVLFPYT FIGLLLALLL SKTCNLLLLD DQVIRHLGID 
241:	ATALRLGISL VAVLLASVAT SIVGVVSFLG LIVPHMSRLL VGSKHQILIP FSALLGAFVF 
301:	LLADTLGRSL AYPLEISPAI IMSIVGGPYF IYLLRRSDII