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3.A.1.14.10
The heme porter, Shp/SiaABC (HtsABC). Shp is a cell surface heme binding protein that transfers the heme directly to HstA (Nygaard et al., 2006). The crystal structure of the heme binding domain of Shp has been solved (Aranda et al., 2007). HtsABC is required for the uptake of staphyloferrin A (Beasley et al. 2009). The Shp cell surface heme receptor feeds iron-heme to the transporter in preparation for uptake (Sun et al. 2010; Ouattara et al., 2010). 

Accession Number:Q99YA4
Protein Name:Putative ABC transporter aka SiaC
Length:278
Molecular Weight:31590.00
Species:Streptococcus pyogenes serotype M1 [301447]
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Heme

Cross database links:

HEGENOM: HBG758042 HBG758042
RefSeq: NP_269805.1    YP_282889.1   
Entrez Gene ID: 3571371    902022   
Pfam: PF00005   
BioCyc: SPYO160490:SPY1793-MONOMER    SPYO293653:M5005_SPY1526-MONOMER   

Gene Ontology

GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity

References (4)

[1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.”  Ferretti J.J.et.al.   11296296
[2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.”  Sumby P.et.al.   16088826
[3] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.”  Ferretti J.J.et.al.   11296296
[4] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.”  Sumby P.et.al.   16088826

External Searches:

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  • CDD Search (Conserved Domain Database)
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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSKNSSHIQV QNLSFAYEEK LVLDDLTFSI PKGKITTIMG ANGSGKSTLL QLLTKNLPLK 
61:	QGQVWLEQEE LATISLKAFA KKVAVVHQYH QVVEGLLVGE LVAMARLARR SFFKTTTKED 
121:	EERLAWALEV TALSDYVYRD IQHLSGGEQQ RVWIAMALAQ DTDIIFLDEP TTYLDIKYQL 
181:	DILKLITKIN QELGLTIVLV LHDINQALSL SDHLIGLKDG RLYAQGQPRD LLDQQFIRDV 
241:	FGVELPFVER NGQQFVLTSL VNETNGIRTQ RRDRNKNR