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9.A.48.1.1
The Unconventional Protein Secretion System, UPSS (Giuliani et al., 2011).  Secretes FGF1 and Epimorphin (syntaxin 2) (Hirai et al. 2007)

Accession Number:Q9EQR3
Protein Name:Kcnn1
Length:537
Molecular Weight:59330.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate proteins

Cross database links:

Genevestigator: Q9EQR3
eggNOG: roNOG05804
HEGENOM: HBG443547
RefSeq: NP_115773.2   
Entrez Gene ID: 84036   
Pfam: PF02888    PF07885    PF03530   
KEGG: mmu:84036   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005516 F:calmodulin binding
GO:0016286 F:small conductance calcium-activated potassi...
GO:0006813 P:potassium ion transport

References (4)

[1] “Structure and complex transcription pattern of the mouse SK1 KCa channel gene, KCNN1.”  Shmukler B.E.et.al.   11267657
[2] “Molecular properties of small-conductance Ca2+-activated K+ channels expressed in murine colonic smooth muscle.”  Ro S.et.al.   11557517
[3] “Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes.”  Tuteja D.et.al.   16055520
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSSHSHNGSV GQPLGSGPGF LGWEPVDPEA GRPLQPTQGP GLQMVAKGQP VRLSPGGSRG 
61:	HPQEQEEEEE EEEEEDKTGS GKPPTVSHRL GHRRALFEKR KRLSDYALIF GMFGIVVMVT 
121:	ETELSWGVYT KESLCSFALK CLISLSTVIL LGLVILYHAR EIQLFLVDNG ADDWRIAMTW 
181:	ERVSLISLEL VVCAIHPVPG HYRFTWTARL AFSLVPSAAE ADLDVLLSIP MFLRLYLLAR 
241:	VMLLHSRIFT DASSRSIGAL NRVTFNTRFV TKTLMTICPG TVLLVFSVSS WIVAAWTVRV 
301:	CERYHDKQEV TSNFLGAMWL ISITFLSIGY GDMVPHTYCG KGVCLLTGIM GAGCTALVVA 
361:	VVARKLELTK AEKHVHNFMM DTQLTKRVKN AAANVLRETW LIYKHTRLVK KPDQGRVRKH 
421:	QRKFLQAIHQ AQKLRSVKIE QGKVNDQANT LAELAKAQSI AYEVVSELQA QQEELEARLA 
481:	ALESRLDVLG ASLQALPGLI AQAICPLPPP WPGPGHLATA THSPQSHWLP TMGSDCG