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3.A.1.12.12
The CbcWV/CbcX (choline)/CaiX (carnitine)/BetX (betaine) transporter with 3 binding receptors for distinct quaternary ammonium compounds. Only the ligand-bound receptor binds to the transporter with high affinity (Chen et al., 2010; Thomas et al., 2010).

Accession Number:Q9HTI7
Protein Name:Probable permease of ABC transporter
Length:279
Molecular Weight:30020.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Glycine betaine, Carnitine, Choline

Cross database links:

HEGENOM: HBG592565
Entrez Gene ID: 878443   
Pfam: PF00528   
KEGG: pae:PA5377   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFLTDHKLPL GEQIAGFVDW LTLHGASFFD KISDTLEFLI HGVTNGLLWF NPLVLIALLV 
61:	GLVHFIQRSW GLTVFALASL LLILNLGYWQ ETMETLAQVI FATLVCIAVG VPLGIVAAHK 
121:	PWFYTALRPL LDLMQTVPTF VYLIPTLTLF GLGVVPGLIS TVIFAVAAPI RLTCLGIQDV 
181:	PAELLDAGKA FGCSRWQLLT RIELPHAMPS IAAGITQCIM LSLSMVVIAA LVGADGLGKP 
241:	VVNALNTADI SLGFEAGLAI VLLAILLDRV CKQRAVKGK