TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.6.2.34
Multidrug efflux pump, MexPQ-OpmE; export fluoroquinolones, tetracycline, macrolides and chloramphenicol (Poole, 2008)

Accession Number:Q9HY86
Protein Name:MexP
Length:385
Molecular Weight:41331.00
Species:Pseudomonas aeruginosa GN=mexP PE=4 SV=1 [287]
Location1 / Topology2 / Orientation3: Virion membrane1 / Single-pass type I membrane protein2
Substrate Fluoroquinolones, tetracycline, Macrolides, Chloramphenicol

Cross database links:

HEGENOM: HBG742930
RefSeq: NP_252213.1   
Entrez Gene ID: 879790   
Pfam: PF00529   
BioCyc: PAER208964:PA3523-MONOMER   
KEGG: pae:PA3523   

Gene Ontology

GO:0016020 C:membrane
GO:0008565 F:protein transporter activity
GO:0051301 P:cell division
GO:0009306 P:protein secretion

References (2)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043
[2] “Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa.”  Mima T.et.al.   16301811

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNLRHFIRIT ATLGVAALIA GCGESAPPGA ASAPPSVPVA EVVVRPVTPY AEFTGSLTAV 
61:	EQVELRPRVA GYIQDVTVPE GRLVEKGQQL FLIDPRVFKA AQDAARARLR EAEAAALLAR 
121:	TEHERAELLY ARKVVARERL DSAIASRNAS KAQVDAARAA LDAAQLDLGF TRVTAPIGGR 
181:	VGHIQVTEGN YVTNGVTALT SIVSVDPLYV YFDVDERTYL QALAPTRGRE GEQAPRVKVA 
241:	LLTDESYGRS SRLDFLANAA DRGTGTVRVR AVVDNPDGQL TPGLFAKVRL ETGKPRAQVL 
301:	VADHSIGTDQ GRRYVLVVDE GNKTQYRPVE LGPMVDGLRV VRQGLQPGER IVVKGLVRPD 
361:	MQITPRLAEI DGTPVDLSKT VGAAQ