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2.A.6.2.34
Multidrug efflux pump, MexPQ-OpmE; export fluoroquinolones, tetracycline, macrolides and chloramphenicol (Poole, 2008)

Accession Number:Q9HY88
Protein Name:OpmE
Length:491
Molecular Weight:52797.00
Species:Pseudomonas aeruginosa GN=opmE PE=4 SV=1 [287]
Location1 / Topology2 / Orientation3: Virion membrane1 / Single-pass type I membrane protein2
Substrate Fluoroquinolones, tetracycline, Macrolides, Chloramphenicol

Cross database links:

HEGENOM: HBG759011
RefSeq: NP_252211.1   
Entrez Gene ID: 878905   
Pfam: PF02321   
BioCyc: PAER208964:PA3521-MONOMER   
KEGG: pae:PA3521   

Gene Ontology

GO:0016020 C:membrane
GO:0008289 F:lipid binding
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (2)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043
[2] “Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa.”  Mima T.et.al.   16301811

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKPYLRSSLS ALILLGGCAA VGPDYAPPSA SAPASFGAMP AGIDGSGVEI EWWRGFDEPA 
61:	LESLIQRALA ANLDIALAGA RLDEAKALLR ENREEFLPRG GPAFDYQARR RGEVETPAGQ 
121:	QRDIETYRGA LDASWEIDLF GRVRRSVEAA EAQAGSREAL LRNVQASVAA TVAMSWFQLQ 
181:	GIEAELAVVH DIAGNQRDSL EMVERLVSAG SAHEFDRLRA EALLHNVEAA VPDLERRRAA 
241:	TRNALAVLLA EAPQAFSPPV ARASGERLTL RTLGVGDPAG LLARRADIAA AERNLAAATA 
301:	RIGVETAGLY PQVEVRGSIG LVAGNLDALD ESGTSFNVLN PVIRWALLDR GRVWARIAAS 
361:	EARAQEALIL YDRTVLRALQ ETDDAFNGYG AAADRLRLRL LEATANREAA RLARERFVQG 
421:	DGEYLDVLEA ERSDYLSRRA LSIARTEQRL AVVGIYKALG GGWEACAGAR RCGVATDDTS 
481:	PGVARQRDSR S