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2.A.6.2.39
THe MuxABC-OpmB multidrug (aztreonam, macrolides, novobiocin and tetracycline) resistance efflux pump complex (with two RND-type proteins (MuxB and MuxC)), both required for activity (Mima et al., 2009).

Accession Number:Q9I0V6
Protein Name:Probable Resistance-Nodulation-Cell Division (RND) efflux transporter
Length:1043
Molecular Weight:112315.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Aztreonam, Macrolides, Novobiocin, tetracycline

Cross database links:

HEGENOM: HBG293864
RefSeq: NP_251217.1   
Entrez Gene ID: 882889   
Pfam: PF00873   
BioCyc: PAER208964:PA2527-MONOMER   
KEGG: pae:PA2527   

Gene Ontology

GO:0016020 C:membrane
GO:0005215 F:transporter activity
GO:0051301 P:cell division
GO:0006810 P:transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNPSRPFILR PVATTLLMVA ILLSGLIAYR FLPISALPEV DYPTIQVVTL YPGASPEIMT 
61:	SSITAPLENQ LGQIPGLNEM SSSSSGGASV ITLQFSLQSN LDVAEQEVQA AINAAQSLLP 
121:	NDLPNQPVFS KVNPADAPIL TLAVMSDGMP LPQIQDLVDT RLAQKISQIS GVGLVSISGG 
181:	QRPAVRVRAN PTALAAAGLS LEDLRSTVTS NNLNGPKGSF DGPTRASTLD ANDQLRSADA 
241:	YRDLIIAYKN GSPLRIRDVA SVEDDAENVR LAAWANNLPA VVLNIQRQPG ANVIEVVDRI 
301:	KALLPQLQST LPGNLDVQVL TDRTTTIRAS VKDVQFELAL AVALVVMVTF LFLRNVYATL 
361:	IPSFAVPLSL IGTFGVMYLS GFSINNLTLM ALTIATGFVV DDAIVMVENI ARYLEQGDSP 
421:	LEAALKGSKQ IGFTIISLTF SLIAVLIPLL FMGDVAGRLF REFAITLAVA ILISGFVSLT 
481:	LTPMLSAKLL RHIDEDQQGR FARAAGRVID GLIAQYAKAL RVVLRHQPLT LLVAIATLAL 
541:	TALLYLAMPK GFFPVQDTGV IQGVAEAPQS ISFQAMSERQ RALAEVVLKD PAVASLSSYI 
601:	GVDGSNPTLN TGRLLINLKP HSERDVTASE VIQRLQPELD HLPGIKLYMQ PVQDLTIEDR 
661:	VARTQYQFTL QDADPDVLAE WVPKLVARLQ ELPQLADVAS DWQDKGLQAY LNIDRDTASR 
721:	LGVKLSDIDS VLYNAFGQRL ISTIFTQATQ YRVVLEVAPQ FQLGPQALEQ LYVPSSDGTQ 
781:	VRLSSLAKVE ERHTLLAINH IAQFPSATLS FNLAKGYSLG EAVEAIRGVE ASLELPLSMQ 
841:	GSFRGAALAF EASLSNTLLL ILASVVTMYI VLGILYESFI HPVTILSTLP SAGVGALLAL 
901:	MLAGQEIGIV AIIGIILLIG IVKKNAIMMI DFALDAERNE GKPPHEAIYQ ACLLRFRPIL 
961:	MTTMAALLGA LPLMLAGGAG AELRQPLGIT MVGGLLLSQV LTLFTTPVIY LYFDRLARRW 
1021:	AAWRKQRGLD LNTEAGFDGD AGR