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2.A.6.2.39
THe MuxABC-OpmB multidrug (aztreonam, macrolides, novobiocin and tetracycline) resistance efflux pump complex (with two RND-type proteins (MuxB and MuxC)), both required for activity (Mima et al., 2009).

Accession Number:Q9I0V7
Protein Name:Probable Resistance-Nodulation-Cell Division (RND) efflux transporter
Length:1036
Molecular Weight:111830.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Aztreonam, Macrolides, Novobiocin, tetracycline

Cross database links:

HEGENOM: HBG293864
RefSeq: NP_251216.1   
Entrez Gene ID: 882888   
Pfam: PF00873   
BioCyc: PAER208964:PA2526-MONOMER   
KEGG: pae:PA2526   

Gene Ontology

GO:0016020 C:membrane
GO:0005215 F:transporter activity
GO:0051301 P:cell division
GO:0006810 P:transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLSTPFIRR PVATTLLTLA LLLAGTLSFG LLPVAPLPNV DFPAIVVSAS LPGASPETMA 
61:	SSVATPLERS LGRIAGISEM TSSSSLGSTT VVLVFDLEKD IDGAAREVQA AINGAMSLLP 
121:	SGMPNNPSYR KANPSDMPIM VLTLTSETQS RGEMYDLAST VLAPKLSQVQ GVGQVSIGGS 
181:	SLPAVRVDLN PDAMSQYGLS LDSVRTAIAA ANSNGPKGAV EKDDKHWQVD ANDQLRKARE 
241:	YEPLVIHYNA DNGAAVRLGD VAKVSDSVED VRNAGFSDDL PAVLLIVTRQ PGANIIEATD 
301:	AIHAQLPVLQ ELLGPQVKLN VMDDRSPSIR ASLEEAELTL LISVALVILV VFLFLRNGRA 
361:	TLIPSLAVPV SLIGTFAVMY LCDFSLNNLS LMALIIATGF VVDDAIVVVE NIARRIEEGD 
421:	PPIQAAITGA RQVGFTVLSM TLSLVAVFIP LLLMGGLTGR LFREFAVTLS AAILVSLVVS 
481:	LTLTPMLCAR LLRPLKRPEG ASLARRSDRF FAAFMLRYRA SLGWALEHSR LMVVIMLACI 
541:	AMNLWLFVVV PKGFLPQQDS GRLRGYAVAD QSISFQSLSA KMGEYRKILS SDPAVENVVG 
601:	FIGGGRWQSS NTGSFFVTLK PIGERDPVEK VLTRLRERIA KVPGAALYLN AGQDVRLGGR 
661:	DSNAQYEFTL RSDDLTLLRE WAPKVEAAMR KLPQLVDVNS DSQDKGVQTR LVIDRDRAAT 
721:	LGINVEMVDA VLNDSFGQRQ VSTIFNPLNQ YRVVMEVDQQ YQQSPEILRQ VQVIGNDGQR 
781:	VPLSAFSHYE PSRAPLEVNH QGQFAATTLS FNLAPGAQIG PTREAIMQAL EPLHIPVDVQ 
841:	TSFEGNAGAV QDTQNQMPWL ILLALLAVYI VLGILYESYV HPLTILSTLP SAGVGALLAL 
901:	ILCRSELSLI ALIGIILLIG IVKKNAIMMI DFALEAERNH GLSPREAILE ACMMRFRPIM 
961:	MTTLAALLGA LPLIFGIGGD AALRRPLGIT IVGGLIGSQL LTLYTTPVVY LYLDRLRHWV 
1021:	NQKRGVRTDG ALETPL